Study on relationship between heavy metals exposure and breast cancer

doi:10.3969/j.issn.1004-1524.2017.08.17

›› 2017, Vol. 29 ›› Issue (8): 1353-1357.DOI: 10.3969/j.issn.1004-1524.2017.08.17

• Environmental Science • Previous Articles Next Articles

Study on relationship between heavy metals exposure and breast cancer

SUN Kewang¹, LIU Di², PAN Fengshan², WEI Yanyan^{2, 3}, HOU Dandi², YANG Xiao’e^{2, *}

1. Department of Thyroid and Breast Surgery, Zhejiang Provincial People‘s Hospital/People‘s Hospital of Hangzhou Medical College, Hangzhou 310014, China;
2. Ministry of Education Key Laboratory of Environmental Remediation and Ecological Health/College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China;
3. Guangxi Provincial Key Laboratory of Agricultural Environment and Agricultural Products Quality and Safety, College of Agriculture, Guangxi University, Nanning 530004,China

Received:2017-04-24 Online:2017-08-20 Published:2017-09-06

Abstract

Abstract: To explore the relationship between heavy metals exposure and breast cancer, 96 newly diagnosed cases of breast cancer (cancer group) and 30 matched normal cases (control group) were adopted as study materials, and the contents of heavy metals (Cd, Hg, As, Cr, Pb) in serum and breast tissues were determined by inductively coupled plasma mass spectrometry (ICP-MS). It was shown that Cd, Cr, As and Pb contents in serum and breast tissues in the cancer group were significantly (P<0.05) higher than those in the control group. Logistic regression analysis showed that Cd, Cr, As and Pb contents in the serum were associated with breast cancer risk. ORs of Cd, Cr, As and Pb were 12.364 (95%CI: 3.405-44.889), 132 (95%CI: 14.257-1 222.1), 4.941 (95%CI: 1.521-16.047) and 7.416 (95% CI: 0.326-9.980), respectively, indicating that exposure to environmental heavy metals such as Cd, Cr, As and Pb may be one of the risk factors for breast cancer.

Key words: breast cancer, heavy metals, environmental pollution

CLC Number:

X503.1

SUN Kewang, LIU Di, PAN Fengshan, WEI Yanyan, HOU Dandi, YANG Xiao’e. Study on relationship between heavy metals exposure and breast cancer[J]. , 2017, 29(8): 1353-1357.

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Study on relationship between heavy metals exposure and breast cancer

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