Advances in porcine Toll-like receptor family (TLRs) and its application in resistance breeding

doi:10.3969/j.issn.1004-1524.2018.03.21

›› 2018, Vol. 30 ›› Issue (3): 507-520.DOI: 10.3969/j.issn.1004-1524.2018.03.21

• Review • Previous Articles

Advances in porcine Toll-like receptor family (TLRs) and its application in resistance breeding

DAI Chaohui¹, FENG Haiyue¹, WU Shenglong^1,2, BAO Wenbin^1,2,*

1. College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China;
2. Jiangsu Engineering Research Center for the Reproduction and Healthy Breeding of Boar, Yangzhou 225009, China

Received:2017-06-27 Online:2018-03-20 Published:2018-03-21

Abstract

Abstract: Toll-like receptors (TLRs), as pattern recognition receptors, can not only recognize body's specific ligands and start signal transduction through a variety of signaling pathways (mediated by myeloid differentiation protein 88 or by the TLR domain protein of beta-interferon), which leads to specific immune responses, but also play important regulatory roles in some immune responses caused by mycoplasma, viruses, bacteria and other pathogens. Toll-like receptor family has become research hotspots in recent years because of its important immune regulations, which has important scientific significance and application prospect for the breeding of livestock and poultry. The types, functions, heritable variation and mediated signaling pathways of pig Toll-like receptor family were reviewed in this article, and the application of pig TLRs in disease resistance breeding was introduced intensively, which aimed to provide reference and basis for the research of gene function of pig Toll-like receptor family and screening effective genetic markers.

Key words: pig, Toll-like receptor, immune response, resistance breeding

CLC Number:

S813.3

DAI Chaohui, FENG Haiyue, WU Shenglong, BAO Wenbin. Advances in porcine Toll-like receptor family (TLRs) and its application in resistance breeding[J]. , 2018, 30(3): 507-520.

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Advances in porcine Toll-like receptor family (TLRs) and its application in resistance breeding

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