RNA干扰机制及其主要蛋白因子研究进展

›› 2011, Vol. 23 ›› Issue (2): 0-420.

• 综述 •

RNA干扰机制及其主要蛋白因子研究进展

和琼姬1,2 ,燕飞2 ,陈剑平2,*

1浙江师范大学化学与生命科学学院,浙江金华 321004；2浙江省农业科学院病毒学与生物技术研究所,浙江杭州 310021

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-03-25 发布日期:2011-03-25

Advance of RNA interference (RNAi) mechanism and the main proteins in RNAi

HE Qiong-ji;YAN Fei;CHEN Jian-ping;*

1 College of Chemistry and Life Science, Zhejiang Normal University , Jinhua 321004, China; 2 Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Science, Hangzhou 310021, China

Received:1900-01-01 Revised:1900-01-01 Online:2011-03-25 Published:2011-03-25

摘要/Abstract

摘要： RNA干扰(RNA interference, RNAi)是由双链RNA(double stranded RNA, dsRNA)分子介导的、在mRNA水平上关闭相应序列基因表达、使其沉默的过程。RNAi作为一种古老而保守的基因沉默机制,广泛存在于真核生物体内,在细胞的发育调控、抗病毒防御、修复遗传损伤、调节正常的基因等生命过程中起着重要的作用。RNAi机制可以分为3个阶段：启动阶段、效应阶段及扩增阶段。RNAi干扰相关的主要蛋白因子有Dicer酶、Argonaute(AGO) 蛋白家族和RNA依赖的RNA聚合酶(RNA\|dependent RNA polymerase, RdRP)。文章对RNAi机制及其相关主要蛋白因子进行简要综述。

关键词: RNAi, Dicer, Argonaute, RdRP

Abstract: RNA interference (RNAi) is a process induced by double stranded RNA and regulates the corresponding gene expression and gene silencing at mRNA level. As a conserved mechanism, it functions in kinds of eukaryotes and participates into the development regulation, antivirus defense, genetic damage repair, gene expression regulation and other important processes of life. There are initiation step, effecter step and amplification step in RNAi pathway where Dicer, AGO, RdRP and other proteins function alone or together. Here, we reviewed the advance of RNAi mechanism and functions of the main proteins in RNAi．

Key words: RNAi, Dicer, Argonaute, RdRP

和琼姬;燕飞;陈剑平;* . RNA干扰机制及其主要蛋白因子研究进展[J]. , 2011, 23(2): 0-420.

HE Qiong-ji;YAN Fei;CHEN Jian-ping;*. Advance of RNA interference (RNAi) mechanism and the main proteins in RNAi[J]. , 2011, 23(2): 0-420.

RNA干扰机制及其主要蛋白因子研究进展

Advance of RNA interference (RNAi) mechanism and the main proteins in RNAi

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