关键词: MUC13, 仔猪腹泻, 调控网络

Abstract: This study developed a regulation network of piglets diarrhea in which MUC13 gene participated and made an assay of gene functional annotation clustering. Firstly， 10 MUC13\|associated proteins were generated through STRING 90 （MUC4， MUC20， LRCH3， FLJ33471， ACK， ZDHHC19， CTPCT， APOD， Msp， CD71）. Secondly， using the 10 MUC13\|associated proteins， we developed a regulation network of piglets diarrhea in which MUC13 gene participated， which included MUC13， MUC4， MUC1， MUC2， MUC3， TFF3， NOD1， TNFSF10， FGFR1， CDH2 genes. Finally， with DAVID bioinformatics resources， we made an assay of gene functional annotation clustering， and found specific functional annotations terms included domain: SEA， extracellular region， transmembrane protein， so we speculated that the specific structure of the MUC13 determined MUC13 had a specific function in the development process of piglet diarrhea. The network constructed in this study has certain authenticity and can be used for describing molecular interactions in the occurrence and development of piglet diarrhea， which is important to elucidate the molecular mechanisms of diarrhea occurrence.

Key words: MUC13, piglet diarrhea, regulation network