Abstract: In order to provide scientific basis for control of canine parvovirus infection， an epidemiological investigation on the infected dogs was carried out from October 2011 to September 2012 in Wenzhou Small Animal Hospital， Wenzhou Vocational College of Science ＆ Technology. The results showed that 113 canine parvovirus positive cases were found and the total infection rate was 196%. The majority of infection cases were dogs at the age of 3 months to 12 months. The infection rate among the dogs with no immunization were was higher, accounting for 84.8%. And the infection rate of purebred dogs was higher， accounting for 841%. Canine parvovirus infection could happen all the year round in Wenzhou area， especially in spring and autumn. The comprehensive treatment including injection of CPV serum and CPV monoclonal antibody and active immunization were adopted to improve cure rate and reduce mortality of canine parvovirus infection．

Key words: canine parvovirus infection, epidemiological investigation, Wenzhou area