Abstract: The aiming of this study was evaluating if the Chinese herbal medicine Lycium barbarum polysaccharides had hepatoprotective effects against CCl4-induced liver accurate injury in Cyprinnus var. Jian. The carps were randomly divided into 6 treatment groups， which named blank the control group （Ctrl）， model group （CCl4）， Lycium barbarum polysaccharides drug the control group （LBP Ctrl）， experimental group （LBP 0.1 g·kg-1，0.5 g·kg-1，1.0 g·kg-1）. After fed for 60 days， the model group and Lycium barbarum polysaccharides drug control group were injected （i. p） with 30%（V/V） of CCl4 in arachis oil at a volume of 005mL·10g-1 of body weight， after 72 h ， the liver samples and blood were collected for detccting glutamic pyruvic transaminase （GPT）， glutamate oxalate transaminase （GOT）， lactatedehydrogenase （LDH）， superoxide dismutase （SOD）， malondialdehyde （MDA），totalprotein （TP）， lbumin （Alb）， catalase （CAT）， glutathione peroxidase （GSH\|Px）， Glutathione （GSH） and total antioxidant capacity （T\|AOC）. The results showed that CCl4 could induce the liver injury of Jian Carp; the 10 g·kg-1 LBP could effectively reduce the value of GPT， GOT， LDH and MDA and improve the value of T-AOC， CAT， GSH-Px， SOD， GSH and TP （P＜0.05）; 0.5 g·kg-1LBP could effectively reduce the value of GPT and improve the value of T-AOC， SOD. But 0.1 g·kg-1 LBP had no obvious changes on these indexes. From the above results， it can be indicated that LBP had hepatoprotective effects against carbon tertrachloride （CCl4）-induced liver accurate injury， and could be used for fish liver disease prevention and control.

Key words: Lycium barbarum polysaccharides, acute liver injury, CCl4, Carprinus carpiovar Jian