Research progress of polyphenols in macrofungi of sanghuang fungi

doi:10.3969/j.issn.1004-1524.20230354

Acta Agriculturae Zhejiangensis ›› 2024, Vol. 36 ›› Issue (3): 704-718.DOI: 10.3969/j.issn.1004-1524.20230354

• Review • Previous Articles Next Articles

Research progress of polyphenols in macrofungi of sanghuang fungi

RUAN Xinying¹^,²(), SONG Tingting², ZHANG Zuofa², JIN Qunli², CHEN Chun¹, CAI Weiming²^,^*()

1. College of Life Sciences, China Jiliang University, Hangzhou 310019, China
2. Institute of Horticulture, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China

Received:2023-03-16 Online:2024-03-25 Published:2024-04-09

Abstract

Abstract:

Sanghuang fungi are a general term of macrofungi belonging to Hymenochaetales with medicinal value and similar appearance. Because of their anti-tumor, anti-oxidation, liver protection, anti-inflammatory and other effects, they are highly favored by consumers, especially Asians. Polyphenols, as important secondary metabolites and one of the key active substances in sanghuang fungi, have been the focus of attention in the field of medicine and health care. On the basis of identifying the groups of sanghuang fungi, this paper reviewed the research progress of different polyphenols in sanghuang fungi, their pharmacological activities, extraction methods and metabolic regulation, and looked forward to the future research direction of sanghuang polyphenols.

Key words: medical fungi, sanghuang fungi, polyphenols, research progress

CLC Number:

S567.3

RUAN Xinying, SONG Tingting, ZHANG Zuofa, JIN Qunli, CHEN Chun, CAI Weiming. Research progress of polyphenols in macrofungi of sanghuang fungi[J]. Acta Agriculturae Zhejiangensis, 2024, 36(3): 704-718.

Figures/Tables 3

References 103

[1]	甄权. 药性论[M]. 尚志钧, 辑释. 合肥: 安徽科学技术出版社, 2006: 1-346.
[2]	包海鹰, 杨烁, 李庆杰, 等. “桑黄” 的本草补充考证[J]. 菌物研究, 2017, 15(4): 264-270.
	BAO H Y, YANG S, LI Q J, et al. Supplementary textual research on “Sanghuang”[J]. Journal of Fungal Research, 2017, 15(4): 264-270. (in Chinese with English abstract)
[3]	陈万超, 杨焱, 张劲松, 等. 桑黄类真菌活性代谢产物的研究进展[J]. 食用菌学报, 2020, 27(4): 188-201.
	CHEN W C, YANG Y, ZHANG J S, et al. Recent advances in bioactive metabolites from ‘Sanghuang’ mushrooms[J]. Acta Edulis Fungi, 2020, 27(4): 188-201. (in Chinese with English abstract)
[4]	WANG H, MA J X, WU D M, et al. Identifying bioactive ingredients and antioxidant activities of wild Sanghuangporus species of medicinal fungi[J]. Journal of Fungi, 2023, 9(2): 242.
[5]	SARFRAZ A, RASUL A, SARFRAZ I, et al. Hispolon: a natural polyphenol and emerging cancer killer by multiple cellular signaling pathways[J]. Environmental Research, 2020, 190: 110017.
[6]	WANG Y, MO S Y, WANG S J, et al. A unique highly oxygenated pyrano[4, 3-c][2]benzopyran-1, 6-dione derivative with antioxidant and cytotoxic activities from the fungus Phellinus igniarius[J]. Organic Letters, 2005, 7(9): 1675-1678.
[7]	HUANG S C, KUO P C, HUNG H Y, et al. Ionone derivatives from the Mycelium of Phellinus linteus and the inhibitory effect on activated rat hepatic stellate cells[J]. International Journal of Molecular Sciences, 2016, 17(5): 681.
[8]	邵晨霞, 唐少军, 杨祎, 等. 莲子壳栽培桑黄及子实体抑菌活性研究[J]. 中国食用菌, 2022, 41(9): 34-39.
	SHAO C X, TANG S J, YANG Y, et al. Study on Inonotus hispidus cultivated with Lotus seed shell and the antibacterial activity of fruit body[J]. Edible Fungi of China, 2022, 41(9): 34-39. (in Chinese with English abstract)
[9]	AWADH ALI N A, MOTHANA R A A, LESNAU A, et al. Antiviral activity of Inonotus hispidus[J]. Fitoterapia, 2003, 74(5): 483-485.
[10]	LAI M C, LIU W Y, LIOU S S, et al. Hispidin in the medicinal fungus protects dopaminergic neurons from JNK activation-regulated mitochondrial-dependent apoptosis in an MPP(+)-induced in vitro model of Parkinson’s disease[J]. Nutrients, 2023, 15(3): 549.
[11]	YANG K, ZHANG S, GENG Y, et al. Anti-inflammatory properties in vitro and hypoglycaemic effects of phenolics from cultivated fruit body of Phellinus baumii in type 2 diabetic mice[J]. Molecules, 2021, 26(8): 2285.
[12]	陈林杰, 程俊文, 魏海龙, 等. 基于聚类和主成分分析法的不同产地桑黄红外指纹图谱研究[J]. 中国食品添加剂, 2020, 31(9): 1-7.
	CHEN L J, CHENG J W, WEI H L, et al. Study on infrared fingerprint of Sanghuangporus sanghuang powder from different origins with cluster analysis and principal component analysis[J]. China Food Additives, 2020, 31(9): 1-7. (in Chinese with English abstract)
[13]	昝立峰, 范宇光, 包海鹰, 等. 基于UPLC-QTOF-MS技术分析野生与栽培杨树桑黄的化学成分[J]. 天然产物研究与开发, 2021, 33(11): 1818-1828, 1886.
	ZAN L F, FAN Y G, BAO H Y, et al. Characterization of chemical compositions from the wild and cultivated Sanghuangporus vaninii based on UPLC-QTOF-MS[J]. Natural Product Research and Development, 2021, 33(11): 1818-1828, 1886. (in Chinese)
[14]	吕国英, 宋婷婷, 蔡为明, 等. 野生桑树桑黄和杨树桑黄化学成分及抗氧化活性比较[J]. 菌物学报, 2021, 40(7): 1833-1843.
	LV G Y, SONG T T, CAI W M, et al. Comparative study of chemical components and antioxidant Sanghuang and Sanghuangporus vaninii[J]. Mycosystema, 2021, 40(7): 1833-1843. (in Chinese with English abstract)
[15]	吴声华. 珍贵药用菌“桑黄” 物种正名[J]. 食药用菌, 2012, 20(3): 177-179.
	WU S H. Correcting the species of precious medicinal fungus “Phellinus igniarius”[J]. Edible and Medicinal Mushrooms, 2012, 20(3): 177-179. (in Chinese)
[16]	WU S H, DAI Y C, HATTORI T, et al. Species clarification for the medicinally valuable ‘Sanghuang’ mushroom[J]. Botanical Studies, 2012, 53: 135-149.
[17]	蔡为明, 金群力, 郑社会, 等. 浙江野生桑黄的生长特征与初步鉴定结果[J]. 食药用菌, 2012, 20(4): 235-236.
	CAI W M, JIN Q L, ZHENG S H, et al. Growth characteristics and preliminary identification results of wild Phellinus igniarius in Zhejiang Province[J]. Edible and Medicinal Mushrooms, 2012, 20(4): 235-236. (in Chinese)
[18]	吴声华, 黄冠中, 陈愉萍, 等. 桑黄的分类及开发前景[J]. 菌物研究, 2016, 14(4): 187-200.
	WU S H, HUANG G Z, CHEN Y P, et al. Taxonomy and development prospects of Sanghuang (Sanghuangporus sanghuang)[J]. Journal of Fungal Research, 2016, 14(4): 187-200. (in Chinese with English abstract)
[19]	包海鹰, 王超儀, 图力古尔. “桑黄”的本草考证[J]. 菌物学报, 2013, 32(增刊): 70-78.
	BAO H Y, WANG C Y, BAU T. Herbalogical textual research on “Sanghuang”[J]. Mycosystema, 2013, 32(Suppl.): 70-78. (in Chinese with English abstract)
[20]	ZHOU L W, VLASÁK J, DECOCK C, et al. Global diversity and taxonomy of the Inonotus linteus complex (Hymenochaetales, Basidiomycota): Sanghuangporus gen. nov., Tropicoporus excentrodendri and T. guanacastensis gen. et spp. nov., and 17 new combinations[J]. Fungal Diversity, 2016, 77(1): 335-347.
[21]	侯伟男, 朝克吐, 图力古尔. 蒙古桑黄: 中国桑黄孔菌属一新种[J]. 菌物学报, 2023, 42(4): 874-882.
	HOU W N, CHAO K T, BAU T. A new species of Sanghuangporus (Hymenochaetales, Basidiomycota) from Inner Mongolia of China[J]. Mycosystema, 2023, 42(4): 874-882. (in Chinese with English abstract)
[22]	吴声华, 戴玉成. 药用真菌桑黄的种类解析[J]. 菌物学报, 2020, 39(5): 781-794.
	WU S H, DAI Y C. Species clarification of the medicinal fungus Sanghuang[J]. Mycosystema, 2020, 39(5): 781-794. (in Chinese with English abstract)
[23]	柴倩倩. 吉林省桑黄菌“产业-创新-人才”发展模式引领大学生创业[J]. 中国食用菌, 2019, 38(11): 132-134.
	CHAI Q Q. The development model of Phellinus igniarius “industry-innovation-talent” in Jilin Province leads college students to start their own businesses[J]. Edible Fungi of China, 2019, 38(11): 132-134. (in Chinese)
[24]	杨焱, 陈晓华, 戴玉成, 等. 我国桑黄产业发展现状、问题及展望:桑黄产业发展千岛湖宣言[J]. 菌物学报, 2023, 42(4): 855-873.
	YANG Y, CHEN X H, DAI Y C, et al. Sanghuang industry in China: current status, challenges and perspectives: the Qiandao Lake declaration for Sanghuang industry development[J]. Mycosystema, 2023, 42(4): 855-873. (in Chinese with English abstract)
[25]	LIU K, XIAO X, WANG J L, et al. Polyphenolic composition and antioxidant, antiproliferative, and antimicrobial activities of mushroom Inonotus sanghuang[J]. LWT-Food Science and Technology, 2017, 82: 154-161.
[26]	昝立峰, 包海鹰, 李丹花. “桑黄” 类真菌中多酚物质及其生物活性研究进展[J]. 天然产物研究与开发, 2016, 28(1): 147-155.
	ZAN L F, BAO H Y, LI D H. Review on polyphenol components from medicinal fungi “Sanghuang” and their biological activity[J]. Natural Product Research and Development, 2016, 28(1): 147-155. (in Chinese with English abstract)
[27]	HWANG E I, YUN B S, KIM Y K, et al. Phellinsin A, a novel chitin synthases inhibitor produced by Phellinus sp. PL3[J]. The Journal of Antibiotics, 2000, 53(9): 903-911.
[28]	宋吉玲, 陈佳慧, 王战伟, 等. 药用真菌桑黄抗氧化活性及化学成分分析[J]. 长春师范大学学报, 2023, 42(2): 84-88.
	SONG J L, CHEN J H, WANG Z W, et al. Analysis of antioxidant activity and chemical constituents of medicinal fungus Phellinus igniarius[J]. Journal of Changchun Normal University, 2023, 42(2): 84-88. (in Chinese with English abstract)
[29]	WANGUN H V K, HÄRTL A, TAM KIET T, et al. Inotilone and related phenylpropanoid polyketides from Inonotus sp. and their identification as potent COX and XO inhibitors[J]. Organic & Biomolecular Chemistry, 2006, 4(13): 2545-2548.
[30]	MIN B S, YUN B S, LEE H K, et al. Two novel furan derivatives from Phellinus linteus with anti-complement activity[J]. Bioorganic & Medicinal Chemistry Letters, 2006, 16(12): 3255-3257.
[31]	刘凡, 庞道睿, 邹宇晓, 等. 桑黄总黄酮含量及其体外抗氧化活性研究[J]. 中国食用菌, 2014, 33(2): 47-49, 56.
	LIU F, PANG D R, ZOU Y X, et al. The total flavone content and in vitro antioxidant activity of Phellinus sp[J]. Edible Fungi of China, 2014, 33(2): 47-49, 56. (in Chinese)
[32]	谭和平, 邹燕, 叶善蓉, 等. 茶叶中的多酚类物质及其分析方法综述[J]. 中国测试技术, 2008(4): 4-11.
	TAN H P, ZOU Y, YE S R, et al. Review of tea polyphenols analyses for tea[J]. China Measurement & Testing Technology, 2008(4): 4-11. (in Chinese with English abstract)
[33]	吕国英, 宋婷婷, 张洋洋, 等. 基于UPLC-triple-TOF-MS/MS比较桑树桑黄和瓦尼桑黄发酵产物的抗氧化活性[J]. 菌物学报, 2023, 42(4): 939-948.
	LÜ G Y, SONG T T, ZHANG Y Y, et al. A comparative study on antioxidant activities of fermentation products of Sanghuangporus sanghuang and S. vaninii based on UPLC-triple-TOF-MS[J]. Mycosystema, 2023, 42(4): 939-948. (in Chinese with English abstract)
[34]	昝立峰, 包海鹰. 粗毛纤孔菌的研究进展[J]. 食用菌学报, 2011, 18(1): 78-82.
	ZAN L F, BAO H Y. Progress in Inonotus hispidus research[J]. Acta Edulis Fungi, 2011, 18(1): 78-82. (in Chinese with English abstract)
[35]	HWANG B S, LEE I K, CHOI H J, et al. Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii[J]. Bioorganic & Medicinal Chemistry Letters, 2015, 25(16): 3256-3260.
[36]	LEE I K, YUN B S. Hispidin analogs from the mushroom Inonotus xeranticus and their free radical scavenging activity[J]. Bioorganic & Medicinal Chemistry Letters, 2006, 16(9): 2376-2379.
[37]	LEE I K, HAN M S, LEE M S, et al. Styrylpyrones from the medicinal fungus Phellinus baumii and their antioxidant properties[J]. Bioorganic & Medicinal Chemistry Letters, 2010, 20(18): 5459-5461.
[38]	LEE I K, SEOK S J, KIM W K, et al. Hispidin derivatives from the mushroom Inonotus xeranticus and their antioxidant activity[J]. Journal of Natural Products, 2006, 69(2): 299-301.
[39]	王钦博, 杨焱, 冯娜, 等. 桑黄抗氧化活性化合物的分离纯化及结构解析[J]. 天然产物研究与开发, 2013, 25(1): 17-21, 75.
	WANG Q B, YANG Y, FENG N, et al. Separation, purification and structural analysis of antioxidative compound from Phellinus baumii[J]. Natural Product Research and Development, 2013, 25(1): 17-21, 75. (in Chinese)
[40]	LEE I K, JUNG J Y, SEOK S J, et al. Free radical scavengers from the medicinal mushroom Inonotus xeranticus and their proposed biogenesis[J]. Bioorganic & Medicinal Chemistry Letters, 2006, 16(21): 5621-5624.
[41]	吴长生. 药用真菌桑黄化学成分的研究[D]. 济南: 山东大学, 2011.
	WU C S. Chemical constituents of the medicinal fungus Phellinus baumii[D]. Jinan: Shandong University, 2011. (in Chinese with English abstract)
[42]	莫顺燕, 杨永春, 石建功. 桑黄化学成分研究[J]. 中草药, 2004, 35(10): 339-341.
	MO S Y, YANG Y C, SHI J G. Studies on chemical constitutes of Phellinus igniarius[J]. Chinese Traditional and Herbal Drugs, 2004, 35(10): 339-341. (in Chinese)
[43]	莫顺燕, 杨永春, 石建功. 桑黄黄酮A和B的分离与合成[J]. 化学学报, 2003, 61(7): 1161-1163.
	MO S Y, YANG Y C, SHI J G. Isolation and synthesis of phelligrins A and B[J]. Acta Chimica Sinica, 2003, 61(7): 1161-1163. (in Chinese with English abstract)
[44]	杨树东, 包海鹰, 王辉. 粗毛纤孔菌的化学成分及抗肿瘤活性成分[J]. 菌物学报, 2019, 38(1): 127-133.
	YANG S D, BAO H Y, WANG H. Chemical components and anti-tumour compounds from Inonotus hispidus[J]. Mycosystema, 2019, 38(1): 127-133. (in Chinese with English abstract)
[45]	崔诗遥. 桑黄多酚类化合物的成分鉴定及其抗肿瘤作用机制研究[D]. 杭州: 浙江大学, 2022.
	CUI S Y. Research of the constituent characterization of Phellinus baumii polyphenols and its antitumor mechanism[D]. Hangzhou: Zhejiang University, 2022. (in Chinese with English abstract)
[46]	IKEKAWA T, NAKANISHI M, UEHARA N, et al. Antitumor action of some basidiomycetes, especially Phllinus linteus[J]. Gan, 1968, 59(2): 155-157.
[47]	HUANG G J, YANG C M, CHANG Y S, et al. Hispolon suppresses SK-Hep1 human hepatoma cell metastasis by inhibiting matrix metalloproteinase-2/9 and urokinase-plasminogen activator through the PI3K/Akt and ERK signaling pathways[J]. Journal of Agricultural and Food Chemistry, 2010, 58(17): 9468-9475.
[48]	HUANG G J, DENG J S, HUANG S S, et al. Hispolon induces apoptosis and cell cycle arrest of human hepatocellular carcinoma Hep3B cells by modulating ERK phosphorylation[J]. Journal of Agricultural and Food Chemistry, 2011, 59(13): 7104-7113.
[49]	昝立峰, 郭海燕, 包海鹰, 等. 鲍姆桑黄子实体提取物的体外细胞毒活性及其化学成分分析[J]. 菌物学报, 2023, 42(4): 961-972.
	ZAN L F, GUO H Y, BAO H Y, et al. Characterization of cytotoxicity and chemical constituents of extracts of Sanghuangporus baumii basidiomata[J]. Mycosystema, 2023, 42(4): 961-972. (in Chinese with English abstract)
[50]	黄进, 杨国宇, 李宏基, 等. 抗氧化剂作用机制研究进展[J]. 自然杂志, 2004, 26(2): 74-78.
	HUANG J, YANG G Y, LI H J, et al. Progress in mechanism studies of antioxidants[J]. Chinese Journal of Nature, 2004, 26(2): 74-78. (in Chinese)
[51]	昝立峰, 梁瑞娟, 包海鹰. 粗毛纤孔菌提取物的抗氧化和抑菌活性研究[J]. 北方园艺, 2015(5): 151-155.
	ZAN L F, LIANG R J, BAO H Y. Antioxidant and antimicrobial activities of Inonotus hispidus extracts[J]. Northern Horticulture, 2015(5): 151-155. (in Chinese with English abstract)
[52]	JUNG J Y, LEE I K, SEOK S J, et al. Antioxidant polyphenols from the mycelial culture of the medicinal fungi Inonotus xeranticus and Phellinus linteus[J]. Journal of Applied Microbiology, 2008, 104(6): 1824-1832.
[53]	马婷, 邝晓岚, 蔡婉娜, 等. 黄酮类成分抗肝纤维化作用及其机制的研究进展[J]. 中草药, 2022, 53(13): 4146-4161.
	MA T, KUANG X L, CAI W N, et al. Research progress on effects of flavonoids against hepatic fibrosis and their mechanisms[J]. Chinese Traditional and Herbal Drugs, 2022, 53(13): 4146-4161. (in Chinese with English abstract)
[54]	范建高, 王国良. 脂肪肝与肝纤维化[J]. 肝脏, 1999, 4(2): 99-100.
	FAN J G, WANG G L. Fatty liver and liver fibrosis[J]. Chinese Hepatology, 1999, 4(2): 99-100. (in Chinese)
[55]	CHIU C H, CHANG C C, LIN J J, et al. Styrylpyrones from Phellinus linteus mycelia alleviate non-alcoholic fatty liver by modulating lipid and glucose metabolic homeostasis in high-fat and high-fructose diet-fed mice[J]. Antioxidants, 2022, 11(5): 898.
[56]	KIM J E, TAKANCHE J S, YUN B S, et al. Anti-inflammatory character of phelligridin D modulates periodontal regeneration in lipopolysaccharide-induced human periodontal ligament cells[J]. Journal of Periodontal Research, 2018, 53(5): 816-824.
[57]	WU M S, CHIEN C C, CHENG K T, et al. Hispolon suppresses LPS-or LTA-induced iNOS/NO production and apoptosis in BV-2 microglial cells[J]. The American Journal of Chinese Medicine, 2017, 45(8): 1649-1666.
[58]	冯佳亮. 粗毛纤孔菌中酚酸类成分及抗炎活性研究[D]. 长春: 长春工业大学, 2020.
	FENG J L. Study on phenolic acids and anti-inflammatory activity in Inonotus hispidus[D]. Changchun: Changchun University of Technology, 2020. (in Chinese with English abstract)
[59]	SUABJAKYONG P, SAIKI R, VAN GRIENSVEN L J L D, et al. Polyphenol extract from Phellinus igniarius protects against acrolein toxicity in vitro and provides protection in a mouse stroke model[J]. PLoS One, 2015, 10(3): e0122733.
[60]	刘凡, 庞道睿, 游庭活, 等. 桑黄液体发酵菌丝体提取物抑菌活性研究[J]. 广东农业科学, 2013, 40(18): 69-72.
	LIU F, PANG D R, YOU T H, et al. Antibacterial activity of extracts from fermentation mycelia of Phellinus igniarius[J]. Guangdong Agricultural Sciences, 2013, 40(18): 69-72. (in Chinese with English abstract)
[61]	张艳菊, 赵晓春. 中草药中有效成分的溶剂提取法[J]. 养殖技术顾问, 2009(11): 127.
	ZHANG Y J, ZHAO X C. Solvent extraction method of effective components in Chinese herbal medicines[J]. Technical Advisor for Animal Husbandry, 2009(11): 127. (in Chinese)
[62]	陈志娜, 许嘉敏, 叶韬, 等. 粗毛纤孔菌(Inonotus hispidus)的鉴定及其子实体不同溶剂提取物的抗氧化活性与抑菌活性研究[J]. 食品工业科技, 2018, 39(23): 99-104.
	CHEN Z N, XU J M, YE T, et al. Identification of Inonotus hispidus and antioxidant and antimicrobial activities of different solvent extracts from its fruiting bodies[J]. Science and Technology of Food Industry, 2018, 39(23): 99-104. (in Chinese with English abstract)
[63]	张洋洋, 张作法, 宋婷婷, 等. 深共熔溶剂提取杨树桑黄多酚类物质工艺优化及提取物抗氧化活性研究[J]. 菌物学报, 2022, 41(10): 1694-1703.
	ZHANG Y Y, ZHANG Z F, SONG T T, et al. Optimization of extraction process and examination of antioxidant activities of polyphenols extracted from Sanghuangporus vaninii by using deep eutectic solvent[J]. Mycosystema, 2022, 41(10): 1694-1703. (in Chinese with English abstract)
[64]	谭天伟. 天然产物分离新技术[J]. 化工进展, 2003, 22(7): 665-668.
	TAN T W. New separation and purification methods for natural herbs[J]. Chemical Industry and Engineering Progress, 2003, 22(7): 665-668. (in Chinese with English abstract)
[65]	冯子旺, 俞力超, 李峰, 等. 正交试验优选桑黄多酚超声提取工艺[J]. 中国药房, 2012, 23(3): 221-222.
	FENG Z W, YU L C, LI F, et al. Optimization of ultrasound-assisted extraction of polyphenols from Phellinus igniarius by orthogonal test[J]. China Pharmacy, 2012, 23(3): 221-222. (in Chinese with English abstract)
[66]	陈晓平, 于翠翠. 响应面法优化微波辅助乙醇提取桑黄黄酮工艺的研究[J]. 食品与发酵科技, 2013, 49(4): 31-36.
	CHEN X P, YU C C. Study on optimization of extraction of phelligrins technology of microwave-assisted ethanol by response surface method[J]. Food and Fermentation Technology, 2013, 49(4): 31-36. (in Chinese with English abstract)
[67]	李晓朋. 超临界萃取工艺及其测控技术的研究[D]. 长春: 长春工业大学, 2018.
	LI X P. Research on supercritical fluid extraction technology and its measurement and control technology[D]. Changchun: Changchun University of Technology, 2018. (in Chinese with English abstract)
[68]	张倩, 孙瑞祥, 王妍, 等. 桑黄、蛹虫草超临界CO₂萃取物的抗氧化活性及其黄酮和三萜含量[J]. 食用菌, 2020, 42(5): 65-67.
	ZHANG Q, SUN R X, WANG Y, et al. Antioxidant activity and content of flavonoids and triterpene of supercritical CO₂ extract from Cordyceps militaris and Sanghuangporus sanghuang[J]. Edible Fungi, 2020, 42(5): 65-67. (in Chinese with English abstract)
[69]	刘奥. 桑黄(Inonotus baumii)发酵与桑黄素LA分离耦合工艺研究[D]. 东营: 中国石油大学(华东), 2017.
	LIU A. Study on phelligridin LA fermentation and the integrated fermentation-separation process by Inonotus baumii[D]. Dongying: China University of Petroleum (Huadong), 2017. (in Chinese with English abstract)
[70]	梁峥, 郑光植. 高等植物的次级代谢[J]. 植物生理学通讯, 1981, 17(1): 14-21.
	LIANG Z, ZHENG G Z. Secondary metabolism of higher plants[J]. Plant Physiology Communications, 1981, 17(1): 14-21. (in Chinese)
[71]	赵江华, 房欢, 张大伟. 微生物次级代谢产物生物合成的研究进展[J]. 生物技术通报, 2020, 36(11): 141-147.
	ZHAO J H, FANG H, ZHANG D W. Research progress in biosynthesis of secondary metabolites of microorganisms[J]. Biotechnology Bulletin, 2020, 36(11): 141-147. (in Chinese with English abstract)
[72]	张俊, 颜新培, 李一平, 等. 不同来源和采收时期桑黄子实体的主要活性成分含量比较[J]. 蚕业科学, 2021, 47(6): 568-574.
	ZHANG J, YAN X P, LI Y P, et al. Comparative study on content of main active components in fruiting body of Sanghuang from different sources and harvest stages[J]. Acta Sericologica Sinica, 2021, 47(6): 568-574. (in Chinese with English abstract)
[73]	LI Z J, BAO H Y, HAN C, et al. The regular pattern of metabolite changes in mushroom Inonotus hispidus in different growth periods and exploration of their indicator compounds[J]. Scientific Reports, 2022, 12(1): 14354.
[74]	王一菲, 于晓丹, 田雪梅, 等. 栎生桑黄和忍冬桑黄液体培养过程中发酵液抗氧化能力[J]. 菌物学报, 2019, 38(6): 938-950.
	WANG Y F, YU X D, TIAN X M, et al. Antioxidant activities of Sanghuangporus quercicola and S. lonicericola from fermentation broth in liquid cultivation[J]. Mycosystema, 2019, 38(6): 938-950. (in Chinese with English abstract)
[75]	付立忠, 陆娜, 闫静, 等. 三种桑黄属真菌人工栽培子实体营养、药效成分及抗氧化活性分析评价[J]. 菌物学报, 2021, 40(8): 2148-2158.
	FU L Z, LU N, YAN J, et al. Analyses and evaluation of nutrition, active component and antioxidant activities of fruiting bodies of three species of Sanghuangporus[J]. Mycosystema, 2021, 40(8): 2148-2158. (in Chinese with English abstract)
[76]	谢春芹, 曹正, 王春野, 等. 基于响应曲面法优化桑黄黄酮发酵条件[J]. 江苏农业科学, 2019, 47(13): 222-226.
	XIE C Q, CAO Z, WANG C Y, et al. Optimization of liquid fermentation conditions for flavonoids from medicinal fungus Phellinus linteus based on response surface method[J]. Jiangsu Agricultural Sciences, 2019, 47(13): 222-226. (in Chinese with English abstract)
[77]	张悦, 郑凯, 王茹, 等. 促进桑黄次生代谢物累积的碳氮比及碳氮源优化研究[J]. 黑龙江农业科学, 2019(7): 109-114.
	ZHANG Y, ZHENG K, WANG R, et al. Optimization of C/N ratio and carbon and nitrogen sources for promoting secondary metabolite accumulation in Phellinus igniarius[J]. Heilongjiang Agricultural Sciences, 2019(7): 109-114. (in Chinese with English abstract)
[78]	姜福春, 张赫男, 冯杰, 等. 乙酸镁对桑黄液态发酵合成黄酮类物质的促进研究[J]. 菌物学报, 2017, 36(8): 1141-1151.
	JIANG F C, ZHANG H N, FENG J, et al. Flavonoid synthesis by magnesium acetate stress in liquid fermentation of Sanghuangporus sanghuang[J]. Mycosystema, 2017, 36(8): 1141-1151. (in Chinese with English abstract)
[79]	袁雯雯, 周蓉, 孙梦妮, 等. 一氧化氮对液体发酵瓦尼桑黄多酚和三萜积累的影响[J]. 菌物学报, 2023, 42(4): 932-938.
	YUAN W W, ZHOU R, SUN M N, et al. Effects of nitric oxide on the accumulation of polyphenols and triterpenoids in the submerged cultures of Sanghuangporus vaninii[J]. Mycosystema, 2023, 42(4): 932-938. (in Chinese with English abstract)
[80]	杨佳乐, 范桂枝, 张李香. 秋水仙素诱变对桑黄菌丝生长及活性成分的影响[J]. 北方园艺, 2021(7): 110-116.
	YANG J L, FAN G Z, ZHANG L X. Effects of colchicine mutagenesis on growth and active ingredients in hyphae of Phellinus igniarius[J]. Northern Horticulture, 2021(7): 110-116. (in Chinese with English abstract)
[81]	张赫男, 汪雯翰, 曲德辉, 等. 利用常压室温等离子体诱变技术选育高产黄酮的桑黄菌株[J]. 食用菌学报, 2018, 25(2): 49-55.
	ZHANG H N, WANG W H, QU D H, et al. Rational seletion of Phellinus baumii mutants for improved intracellular flavonoids biosynthesis by atmospheric room temperature plasma mutagenesis[J]. Acta Edulis Fungi, 2018, 25(2): 49-55. (in Chinese with English abstract)
[82]	丁兴红, 温成平, 丁志山, 等. 低能离子射线诱变桑黄菌株SH009的初步研究[J]. 食用菌学报, 2010, 17(2): 15-18.
	DING X H, WEN C P, DING Z S, et al. Generation of Phellinus igniarius mutants with enhanced polysaccharide and flavonoid content using ion implantation[J]. Acta Edulis Fungi, 2010, 17(2): 15-18. (in Chinese with English abstract)
[83]	DONG Y T, MA H L, ZHOU C S, et al. Enhanced mycelium production of Phellinus igniarius(agaricomycetes) using a He-Ne laser with pulsed light[J]. International Journal of Medicinal Mushrooms, 2021, 23(4): 59-69.
[84]	KITA T, IMAI S, SAWADA H, et al. The biosynthetic pathway of curcuminoid in turmeric (Curcuma longa) as revealed by ¹³C-labeled precursors[J]. Bioscience, Biotechnology, and Biochemistry, 2008, 72(7): 1789-1798.
[85]	HYUN M W, YUN Y H, KIM J Y, et al. Fungal and plant phenylalanine ammonia-lyase[J]. Mycobiology, 2011, 39(4): 257-265.
[86]	李春兰. 葡萄果实中莽草酸途径与多酚积累的关系[J]. 现代农业科技, 2010(12): 33-36.
	LI C L. Relationship between shikimate acid pathway and polyphenol accumulation in grape berries[J]. Modern Agricultural Sciences and Technology, 2010(12): 33-36. (in Chinese with English abstract)
[87]	HERRMANN K M. The shikimate pathway as an entry to aromatic secondary metabolism[J]. Plant Physiology, 1995, 107(1): 7-12.
[88]	马小魁, 马瑶, 郭丹丹, 等. 一种合成桑黄高活性黄酮类化合物的方法: CN105671100A[P]. 2016-06-15.
[89]	ZHANG H N, CHEN R B, ZHANG J S, et al. The integration of metabolome and proteome reveals bioactive polyphenols and hispidin in ARTP mutagenized Phellinus baumii[J]. Scientific Reports, 2019, 9(1): 16172.
[90]	SONG T T, XU F, SHEN Y Y, et al. The complete mitochondrial genome of Sanghuangporus vaninii Zhehuang-1 (Hymenochaetales, Basidiomycota)[J]. Mitochondrial DNA Part B, Resources, 2021, 6(3): 1096-1097.
[91]	JIANG J H, WU S H, ZHOU L W. The first whole genome sequencing of Sanghuangporus sanghuang provides insights into its medicinal application and evolution[J]. Journal of Fungi, 2021, 7(10): 787.
[92]	ZHOU Q M, WANG J X, JIANG H, et al. Deep sequencing of the Sanghuangporus vaninii transcriptome reveals dynamic landscapes of candidate genes involved in the biosynthesis of active compounds[J]. Archives of Microbiology, 2021, 203(5): 2315-2324.
[93]	SHAO Y, GUO H W, ZHANG J P, et al. The genome of the medicinal macrofungus Sanghuang provides insights into the synthesis of diverse secondary metabolites[J]. Frontiers in Microbiology, 2019, 10: 3035.
[94]	WANG S X, LIU Z C, WANG X T, et al. Mushrooms do produce flavonoids: metabolite profiling and transcriptome analysis of flavonoid synthesis in the medicinal mushroom Sanghuangporus baumii[J]. Journal of Fungi, 2022, 8(6): 582.
[95]	LIN W P, LIU A, WENG C H, et al. Cloning and characterization of a novel phenylalanine ammonia-lyase gene from Inonotus baumii[J]. Enzyme and Microbial Technology, 2018, 112: 52-58.
[96]	周园园, 辛伽惠, 李子豪, 等. 杨树桑黄查尔酮异构酶基因克隆鉴定与表达分析[J]. 食用菌学报, 2022, 29(4): 10-16.
	ZHOU Y Y, XIN J H, LI Z H, et al. Cloning and expression analysis of Chalcone isomerase gene from Sanghuangporus vaninii[J]. Acta Edulis Fungi, 2022, 29(4): 10-16. (in Chinese with English abstract)
[97]	LI H, JIAO X, ZHOU W L, et al. Enhanced production of total flavones from Inonotus baumii by multiple strategies[J]. Preparative Biochemistry & Biotechnology, 2018, 48(2): 103-112.
[98]	ZHENG W F, MIAO K J, ZHANG Y X, et al. Nitric oxide mediates the fungal-elicitor-enhanced biosynthesis of antioxidant polyphenols in submerged cultures of Inonotus obliquus[J]. Microbiology, 2009, 155(Pt 10): 3440-3448.
[99]	ZHAO Y X, HE M H, DING J N, et al. Regulation of anticancer styrylpyrone biosynthesis in the medicinal mushroom Inonotus obliquus requires thioredoxin mediated transnitrosylation of S-nitrosoglutathione reductase[J]. Scientific Reports, 2016, 6: 37601.
[100]	ZHENG W F, LIU Y B, PAN S Y, et al. Involvements of S-nitrosylation and denitrosylation in the production of polyphenols by Inonotus obliquus[J]. Applied Microbiology and Biotechnology, 2011, 90(5): 1763-1772.
[101]	ZHAO Y X, HE M H, XI Q, et al. Reversible S-nitrosylation limits over synthesis of fungal styrylpyrone upon nitric oxide burst[J]. Applied Microbiology and Biotechnology, 2016, 100(9): 4123-4134.
[102]	ZHAO Y X, XI Q, XU Q, et al. Correlation of nitric oxide produced by an inducible nitric oxide synthase-like protein with enhanced expression of the phenylpropanoid pathway in Inonotus obliquus cocultured with Phellinus morii[J]. Applied Microbiology and Biotechnology, 2015, 99(10): 4361-4372.
[103]	高山林. 提高中药材质量和产量的思路和实践[J]. 世界科学技术, 2006, 8(1): 80-83.
	GAO S L. Ideas and practice in improvement of production output and quality of Chinese medicinal materials[J]. Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology, 2006, 8(1): 80-83. (in Chinese with English abstract)

拉丁学名 Latin name	中文名称 Chinese name	拉丁学名 Latin name	中文名称 Chinese name
S. alpinus	高山桑黄	S. vaninii^d	杨树桑黄
S. baumii^a	暴马桑黄	S. lonicericola^e	小孔忍冬桑黄
S. weigelae	锦带花桑黄	S. zonatus	环区桑黄
S. sanghuang^b	桑树桑黄	S. toxicodendri	漆树桑黄
S. lonicerinus^c	大忍冬桑黄	S. microcystideus	裂蹄桑黄
S. weirianus	韦尔桑黄	S. ligneous	木质桑黄
S. pilatii	皮拉特桑黄	S. quercicola	栎生桑黄
S. mongolicus	蒙古桑黄

拉丁学名 Latin name	中文名称 Chinese name	拉丁学名 Latin name	中文名称 Chinese name
S. alpinus	高山桑黄	S. vaninii^d	杨树桑黄
S. baumii^a	暴马桑黄	S. lonicericola^e	小孔忍冬桑黄
S. weigelae	锦带花桑黄	S. zonatus	环区桑黄
S. sanghuang^b	桑树桑黄	S. toxicodendri	漆树桑黄
S. lonicerinus^c	大忍冬桑黄	S. microcystideus	裂蹄桑黄
S. weirianus	韦尔桑黄	S. ligneous	木质桑黄
S. pilatii	皮拉特桑黄	S. quercicola	栎生桑黄
S. mongolicus	蒙古桑黄

类别 Classify	名称 Compound name	来源 Source
吡喃酮类 Pyrone	牛奶树碱 Hispidin	S. sanghuang, S. vaninii^[33], I. hispidus^[34], S. baumii^[35]
	桑黄酚A Hispolon	S. sanghuang, S. vaninii^[33], I. hispidus^[34]
	Hypholomine B	S. sanghuang, S. vaninii^[33], S. baumii^[35]
	骨碎补内酯 Davallialactone	S. vaninii^[13], S. sanghuang^[14], I. xeranticus^[36], P. baumii^[37]
	纤孔菌素 Inoscavin A	S. vaninii^[13], I. xeranticus^[38], S. sanghuang^[14], S. baumii^[39]
	Baumin	S. vaninii^[13], P. baumii^[37]
	桑黄素D Phelligridin D	S. vaninii^[13], S. sanghuang^[14], S. baumii^[35], I. xeranticus^[40]
呋喃酮类 Furanone	Phellinusfuran A	P. linteus^[30]
	Phellinusfuran B	P. linteus^[30]
	烟碱酮 Inotilone	Inonotus sp.^[29]
黄酮类 Flavonoids	圣草素 Erodcyol	P. baumii^[41], P. igniarius^[42]
	二氢山奈酚 Dihydrokaempferol	P. baumii^[41], P. igniarius^[42]
	7-甲氧基二氢茨非素 4, 5-dihydroxy- 7-methoxy- dihydroflavonol	S. vaninii^[13], P. baumii^[41], P. igniarius^[42]
	柚皮素 Naringenin	S. vaninii^[13]
	桑黄黄酮A Phelligrin A	P. igniarius^[43], S. vaninii^[13]
酚酸类 Phenolic acid	原儿茶酸 Protocatechuic acid	S. sanghuang^[14], S. vaninii^[13],I. xeranticus^[40], P. igniarius^[42], I. hispidus^[44]
	原儿茶醛 Protocatechualdehyde	S. vaninii^[13], S. sanghuang^[14], I. xeranticus^[40], P. igniarius^[42], I. hispidus^[44], P. baumii^[45]
	咖啡酸 Caffeic acid	S. vaninii^[13], P. igniarius^[42], P. baumii^[45]
	没食子酸 Gallic acid	S. vaninii^[13]
儿茶素类 Catechins	儿茶素 Catechin	S. vaninii^[13]
	表没食子儿茶素没食子酸酯 Epigallocatechin gallate	S. vaninii^[13]

类别 Classify	名称 Compound name	来源 Source
吡喃酮类 Pyrone	牛奶树碱 Hispidin	S. sanghuang, S. vaninii^[33], I. hispidus^[34], S. baumii^[35]
	桑黄酚A Hispolon	S. sanghuang, S. vaninii^[33], I. hispidus^[34]
	Hypholomine B	S. sanghuang, S. vaninii^[33], S. baumii^[35]
	骨碎补内酯 Davallialactone	S. vaninii^[13], S. sanghuang^[14], I. xeranticus^[36], P. baumii^[37]
	纤孔菌素 Inoscavin A	S. vaninii^[13], I. xeranticus^[38], S. sanghuang^[14], S. baumii^[39]
	Baumin	S. vaninii^[13], P. baumii^[37]
	桑黄素D Phelligridin D	S. vaninii^[13], S. sanghuang^[14], S. baumii^[35], I. xeranticus^[40]
呋喃酮类 Furanone	Phellinusfuran A	P. linteus^[30]
	Phellinusfuran B	P. linteus^[30]
	烟碱酮 Inotilone	Inonotus sp.^[29]
黄酮类 Flavonoids	圣草素 Erodcyol	P. baumii^[41], P. igniarius^[42]
	二氢山奈酚 Dihydrokaempferol	P. baumii^[41], P. igniarius^[42]
	7-甲氧基二氢茨非素 4, 5-dihydroxy- 7-methoxy- dihydroflavonol	S. vaninii^[13], P. baumii^[41], P. igniarius^[42]
	柚皮素 Naringenin	S. vaninii^[13]
	桑黄黄酮A Phelligrin A	P. igniarius^[43], S. vaninii^[13]
酚酸类 Phenolic acid	原儿茶酸 Protocatechuic acid	S. sanghuang^[14], S. vaninii^[13],I. xeranticus^[40], P. igniarius^[42], I. hispidus^[44]
	原儿茶醛 Protocatechualdehyde	S. vaninii^[13], S. sanghuang^[14], I. xeranticus^[40], P. igniarius^[42], I. hispidus^[44], P. baumii^[45]
	咖啡酸 Caffeic acid	S. vaninii^[13], P. igniarius^[42], P. baumii^[45]
	没食子酸 Gallic acid	S. vaninii^[13]
儿茶素类 Catechins	儿茶素 Catechin	S. vaninii^[13]
	表没食子儿茶素没食子酸酯 Epigallocatechin gallate	S. vaninii^[13]

Research progress of polyphenols in macrofungi of sanghuang fungi

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 3

References 103

Related Articles 3

Recommended Articles

Metrics

Comments

[1]	TIAN Yutan, MA Lu, LIU Juna, LI Dongdong, TAO Yingmei, ZHAO Xiaolu, MA Yanan, SUN Shaoyi, LIU Dunhua. Application of edible composite film of wine residue polyphenol-chitosan-CMC during storage of boiled mutton [J]. Acta Agriculturae Zhejiangensis, 2021, 33(6): 1095-1103.
[2]	WANG Jun\\|hong;GAO Hai\\|yan*;GE Lin\\|mei;CHEN Hang\\|jun;FANG Xiang\\|jun. Technological study on microwave\\|assisted extraction of polyphenols from Sargassum fusiforme [J]. , 2013, 25(6): 0-1372.
[3]	RU Yi;CHENG Anwei;*;WANG Wenliang;JIN Qiong;GONG Zhiqing;WANG Shoujing;. Study on the content of extractable and non\\|extractable polyphenols in onions [J]. , 2013, 25(1): 0-191.