重金属暴露与乳腺癌发病的关系初探

doi:10.3969/j.issn.1004-1524.2017.08.17

浙江农业学报 ›› 2017, Vol. 29 ›› Issue (8): 1353-1357.DOI: 10.3969/j.issn.1004-1524.2017.08.17

重金属暴露与乳腺癌发病的关系初探

孙可望¹, 刘娣², 潘风山², 韦燕燕^{2, 3}, 候丹迪², 杨肖娥^{2, *}

1.浙江省人民医院/杭州医学院附属人民医院甲状腺乳腺外科,浙江杭州310014；
2.浙江大学环境与资源学院/污染环境修复与生态健康教育部重点实验室,浙江杭州 310058；
3.广西大学农学院/广西高校农业环境与农产品质量安全重点实验室(培育),广西南宁 530004

收稿日期:2017-04-24 出版日期:2017-08-20 发布日期:2017-09-06
通讯作者: 杨肖娥,E-mail: xeyang@zju.edu.cn
作者简介:孙可望(1970-),女,浙江仙居人,硕士,主任医师,研究方向为甲状腺乳腺疾病。E-mail: sunkewangwk@hotmail.com
基金资助:
浙江省科技计划项目(2014C33240)

Study on relationship between heavy metals exposure and breast cancer

SUN Kewang¹, LIU Di², PAN Fengshan², WEI Yanyan^{2, 3}, HOU Dandi², YANG Xiao’e^{2, *}

1. Department of Thyroid and Breast Surgery, Zhejiang Provincial People‘s Hospital/People‘s Hospital of Hangzhou Medical College, Hangzhou 310014, China;
2. Ministry of Education Key Laboratory of Environmental Remediation and Ecological Health/College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China;
3. Guangxi Provincial Key Laboratory of Agricultural Environment and Agricultural Products Quality and Safety, College of Agriculture, Guangxi University, Nanning 530004,China

Received:2017-04-24 Online:2017-08-20 Published:2017-09-06

摘要/Abstract

摘要： 收集2012-2014年浙江省人民医院经病理确诊的新发女性原发性乳腺癌病例96例(病例组),以所在医院同期住院的乳腺良性疾病女性30例作为对照(对照组),采用ICP-MS检测血清和乳腺组织中重金属(镉、汞、砷、铬、铅)的含量。结果显示,病例组血清中镉、铬、砷和铅的检出水平显著(P<0.05)高于对照组,且组织样品中镉、铬、砷和铅的含量亦高于对照组。Logistic回归分析显示,血清中镉、铬、砷和铅的含量与乳腺癌发病发生存在关联,OR(比值比)值分别为12.364 (95%置信区间:3.405~44.889)、132(95%置信区间:14.257~1 222.1)、4.941(95%置信区间:1.521~16.047)和7.416(95%置信区间:0.326~9.980),表明环境中镉、铬、砷和铅的暴露与女性乳腺癌的发生可能有一定关联。

关键词: 乳腺癌, 重金属, 环境污染

Abstract: To explore the relationship between heavy metals exposure and breast cancer, 96 newly diagnosed cases of breast cancer (cancer group) and 30 matched normal cases (control group) were adopted as study materials, and the contents of heavy metals (Cd, Hg, As, Cr, Pb) in serum and breast tissues were determined by inductively coupled plasma mass spectrometry (ICP-MS). It was shown that Cd, Cr, As and Pb contents in serum and breast tissues in the cancer group were significantly (P<0.05) higher than those in the control group. Logistic regression analysis showed that Cd, Cr, As and Pb contents in the serum were associated with breast cancer risk. ORs of Cd, Cr, As and Pb were 12.364 (95%CI: 3.405-44.889), 132 (95%CI: 14.257-1 222.1), 4.941 (95%CI: 1.521-16.047) and 7.416 (95% CI: 0.326-9.980), respectively, indicating that exposure to environmental heavy metals such as Cd, Cr, As and Pb may be one of the risk factors for breast cancer.

Key words: breast cancer, heavy metals, environmental pollution

中图分类号:

X503.1

孙可望, 刘娣, 潘风山, 韦燕燕, 候丹迪, 杨肖娥. 重金属暴露与乳腺癌发病的关系初探[J]. 浙江农业学报, 2017, 29(8): 1353-1357.

SUN Kewang, LIU Di, PAN Fengshan, WEI Yanyan, HOU Dandi, YANG Xiao’e. Study on relationship between heavy metals exposure and breast cancer[J]. , 2017, 29(8): 1353-1357.

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重金属暴露与乳腺癌发病的关系初探

Study on relationship between heavy metals exposure and breast cancer

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