丁葵草提取物对小鼠急性炎症抑制作用的研究

doi:10.3969/j.issn.1004-1524.2018.05.10

浙江农业学报 ›› 2018, Vol. 30 ›› Issue (5): 738-743.DOI: 10.3969/j.issn.1004-1524.2018.05.10

丁葵草提取物对小鼠急性炎症抑制作用的研究

陈秀英, 张宇晨, 徐向坤, 冯雪建^*

郑州大学药学院,国家药物安全性评价研究中心,药物关键制备技术教育部重点实验室,河南郑州450001

收稿日期:2017-08-29 出版日期:2018-05-20 发布日期:2018-05-23
通讯作者: 冯雪建,E-mail: fengxj@zzu.edu.cn
作者简介:陈秀英(1981—),女,河南开封人,硕士,讲师,主要从事药理毒理学研究。E-mail: chxy@zzu.edu.cn
基金资助:
河南省博士后科研资助项目(2014016)

Study of anti-inflammatory effects of extracts from Zornia diphylla (L.) Pers in mice

CHEN Xiuying, ZHANG Yuchen, XU Xiangkun, FENG Xuejian^*

College of Pharmaceutical Sciences, Research Center of Zhengzhou University Drug Safety Evaluation, Ministry of Education, Key Laboratory of Advanced Drug Preparation Technologies, Zhengzhou University, Zhengzhou 450001, China

Received:2017-08-29 Online:2018-05-20 Published:2018-05-23

摘要/Abstract

摘要： 通过二甲苯致小鼠耳肿胀试验、角叉菜胶致小鼠足肿胀试验、腹腔毛细血管通透性抑制率的测定及足肿胀部位病理学的分析,探讨丁葵草提取物对急性炎症的作用。结果表明,丁葵草高(20 g·kg^-1)、中剂量 (6.6 g·kg^-1)组可不同程度抑制二甲苯所致的小鼠耳肿胀及角叉菜胶所致的足肿胀作用,降低毛细血管的通透性,减轻足肿胀部位病理学炎症改变及炎症部位前列腺素E₂(PGE₂)渗出。丁葵草具有良好的抗急性炎症作用,其抗炎机制可能与抑制炎症部位PGE₂的产生有关。

关键词: 丁葵草, 抗炎作用, PGE₂, 小鼠

Abstract: The peritoneal capillary permeability test, xylene induced auricular swelling test and carrageenan induced paw edema test were used to study the anti-inflammatory effect of Zornia diphylla (L.) Pers. Compared with the model control group, Zornia diphylla (L.) Pers inhibited the penetration of capillary vessel, decreased the swelling rate of auricle and paw in mice and relieved the pathological changes of the toes swelling and the exudation of PGE₂ in the inflammatory site after intragastric administration for 5 days. These results showed that Zornia diphylla (L.) Pers had inhibitory effects on acute inflammation in mice, and the mechanism may be related to the reduction of PGE₂ in the inflammatory sites.

Key words: Zornia diphylla (L.) Pers, anti-inflammation, PGE₂, mice

中图分类号:

S859

陈秀英, 张宇晨, 徐向坤, 冯雪建. 丁葵草提取物对小鼠急性炎症抑制作用的研究[J]. 浙江农业学报, 2018, 30(5): 738-743.

CHEN Xiuying, ZHANG Yuchen, XU Xiangkun, FENG Xuejian. Study of anti-inflammatory effects of extracts from Zornia diphylla (L.) Pers in mice[J]. , 2018, 30(5): 738-743.

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丁葵草提取物对小鼠急性炎症抑制作用的研究

Study of anti-inflammatory effects of extracts from Zornia diphylla (L.) Pers in mice

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