氯前列醇钠与卡贝缩宫素对荣昌猪和涪陵黑猪母猪分娩时间的影响

doi:10.3969/j.issn.1004-1524.2022.05.05

浙江农业学报 ›› 2022, Vol. 34 ›› Issue (5): 915-922.DOI: 10.3969/j.issn.1004-1524.2022.05.05

氯前列醇钠与卡贝缩宫素对荣昌猪和涪陵黑猪母猪分娩时间的影响

张亮(), 柴捷, 潘红梅(), 郭宗义

重庆市畜牧科学院,重庆 402460

收稿日期:2020-11-13 出版日期:2022-05-25 发布日期:2022-06-06
通讯作者: 潘红梅
作者简介:* 潘红梅,E-mail: panhm_2118@163.com
张亮(1982—),男,重庆人,硕士,副研究员,研究方向为动物繁殖与遗传育种。E-mail: zhang_liang1982@163.com
基金资助:
国家重点研发计划(2017YFD501902);重庆市农发资金项目(19514)

Effects of cloprostol sodium and carbetocin on parturition of sows

ZHANG Liang(), CHAI Jie, PAN Hongmei(), GUO Zongyi

Chongqing Academic of Animal Science, Chongqing 402460, China

Received:2020-11-13 Online:2022-05-25 Published:2022-06-06
Contact: PAN Hongmei

摘要/Abstract

摘要：

氯前列醇钠作为人工合成的前列腺素类似物被广泛的应用于诱导各种母畜的分娩。卡贝缩宫素作为一种具有长效特性的新型催产素类样分子,有望在母猪分娩过程中替代缩宫素起到收缩子宫启动分娩的作用。试验一主要对氯前列醇钠注射部位和剂量进行研究,将母猪随机分为自然分娩组(n=74)、2 mL肌肉注射组(n=52)、2 mL后海穴注射组(n=63)和1 mL后海穴注射组(n=57)。研究结果表明,2 mL后海穴注射组的母猪分娩时间上表现更为集中,产仔持续时间最短(228 min),白天分娩比例最高(90.48%)。说明通过调整母猪注射氯前列醇钠时间、剂量以及部位等因素能够一定程度的缩短母猪产仔时间,提高母猪白天分娩率。试验二主要对卡贝缩宫素(CBT)与氯前列醇钠的联合应用进行研究,试验将母猪随机分为自然分娩组(n=81)、氯前列醇钠注射组(n=70),CBT注射组(n=67),氯前列醇钠+CBT注射组(n=64)。研究结果表明,氯前列醇钠与卡贝缩宫素联合应用能够缩短母猪产仔持续时间(205 min),并且大幅提高母猪在白天工作时间分娩比例(95.31%)。

关键词: 母猪, 诱导分娩, 卡贝缩宫素, 前列腺素, 白天分娩

Abstract:

As a synthetic prostaglandin analog, cloprostol sodium is widely used to induce delivery in various livestock. Carbetocin (CBT) is an oxytocin-like molecule with long-acting properties which targets the same receptors on the myometrium as oxytocin. It is currently considered to be a substitute for oxytocin in the sows to contract the uterus to initiate delivery. The first trial mainly studied the injection site and dosage of cloprostol sodium. The sows were randomly divided into natural delivery group (n=74), 2 mL intramuscular injection group (n=52), 2 mL Houhai acupoint injection group (n=63) and 1 mL Houhai acupoint injection group (n=57). The results of the study showed that the sows in the 2 mL Houhai acupoint injection group showed more synchronized farrowing time, with the shortest farrowing duration (228 min) and the highest daytime delivery rate (90.48%). It was indicated that the sows’ farrowing duration can be shortened and the daytime delivery rate of sows can be improved to a certain extent by adjusting the injection time, dosage and location of sodium cloprostol. The second trial mainly studied the effect of carbetocin (CBT) in combination with cloprostol sodium. The sows were randomly divided into natural delivery group (n=81), cloprostol sodium injection group (n=70), and CBT injection group (n=67), cloprostol sodium+CBT injection group (n=64). The results of the study showed that the combined application of cloprostol sodium and carbetocin could shorten the farrowing duration of sows (205 min), and significantly increased the daytime delivery rate in the working hours (95.31%).

Key words: sows, induced parturition, carbetocin, cloprostol sodium, daytime delivery

中图分类号:

S828

张亮, 柴捷, 潘红梅, 郭宗义. 氯前列醇钠与卡贝缩宫素对荣昌猪和涪陵黑猪母猪分娩时间的影响[J]. 浙江农业学报, 2022, 34(5): 915-922.

ZHANG Liang, CHAI Jie, PAN Hongmei, GUO Zongyi. Effects of cloprostol sodium and carbetocin on parturition of sows[J]. Acta Agriculturae Zhejiangensis, 2022, 34(5): 915-922.

图/表 4

参考文献 20

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季节Season	日出时间Sunrise time	日落时间Sun setting time	昼长Daylength/h	白天时间Daytime
春季Spring	6:07~6:59	19:08~19:40	12.85~0.70	6:30—19:30
夏季Summer	5:56~6:22	19:45~19:53	13.67~0.38	6:00—20:00
秋季Autumn	6:44~7:18	18:05~18.55	11.50~0.70	7:00—18:30
冬季Winter	7:36~7:52	18:04~18:40	10.63~0.38	8:00—18:30

季节Season	日出时间Sunrise time	日落时间Sun setting time	昼长Daylength/h	白天时间Daytime
春季Spring	6:07~6:59	19:08~19:40	12.85~0.70	6:30—19:30
夏季Summer	5:56~6:22	19:45~19:53	13.67~0.38	6:00—20:00
秋季Autumn	6:44~7:18	18:05~18.55	11.50~0.70	7:00—18:30
冬季Winter	7:36~7:52	18:04~18:40	10.63~0.38	8:00—18:30

分组 Treatment	样本量 Sample size	胎次 Parity	注射至分娩时间间隔 Injection-farrowing interval/h	白天产仔比例 Daytime farrowing ratio/%	产仔持续时间 Farrowing duration/min	总产仔数 Total number born	活产仔数 Number born alive
空白对照组	74	4.88±2.56	28.90±22.10	55.41(41/74)	262±144	11.20±2.45	10.52±2.38
Control group
2 mL氯前列醇钠组 (肌肉注射)	52	4.67± 2.43	24.23±13.67	86.54(45/52)	254±137	11.54±2.04	10.30±2.61
2 mL Cloprostenol sodium (intramuscular injection group)
2 mL氯前列醇钠 (后海穴注射)	63	4.55±2.76	23.88±7.53	90.48(57/63)	228±101	11.29±2.26	10.60±2.82
2 mL Cloprostenol sodium (Houhai acupoint injection group)
1 mL氯前列醇钠 (后海穴注射)	57	4.78±2.86	23.42±10.28	78.95(45/57)	237±109	11.35±2.53	10.40±2.54
1 mL Cloprostenol sodium (Houhai acupoint injection group)

分组 Treatment	样本量 Sample size	胎次 Parity	注射至分娩时间间隔 Injection-farrowing interval/h	白天产仔比例 Daytime farrowing ratio/%	产仔持续时间 Farrowing duration/min	总产仔数 Total number born	活产仔数 Number born alive
空白对照组	74	4.88±2.56	28.90±22.10	55.41(41/74)	262±144	11.20±2.45	10.52±2.38
Control group
2 mL氯前列醇钠组 (肌肉注射)	52	4.67± 2.43	24.23±13.67	86.54(45/52)	254±137	11.54±2.04	10.30±2.61
2 mL Cloprostenol sodium (intramuscular injection group)
2 mL氯前列醇钠 (后海穴注射)	63	4.55±2.76	23.88±7.53	90.48(57/63)	228±101	11.29±2.26	10.60±2.82
2 mL Cloprostenol sodium (Houhai acupoint injection group)
1 mL氯前列醇钠 (后海穴注射)	57	4.78±2.86	23.42±10.28	78.95(45/57)	237±109	11.35±2.53	10.40±2.54
1 mL Cloprostenol sodium (Houhai acupoint injection group)

分组 Treatment	样本量 Sample size	胎次 Parity	注射至分娩时间间隔 Injection-farrowing interval/h	白天产仔比例 Daytime farrowing ratio/%	产仔持续时间 Farrowing duration/min
2 mL氯前列醇钠组(肌肉注射)	41	初产Primiparity	23.68±9.26	85.37(35/41)	274±32 a
2 mL Cloprostenol sodium (intramuscular injection group)
2 mL氯前列醇钠(后海穴注射)	131	经产Multiparity	23.94±11.36	85.50(112/131)	230±19 b
2 mL Cloprostenol sodium (Houhai acupoint injection group)

氯前列醇钠与卡贝缩宫素对荣昌猪和涪陵黑猪母猪分娩时间的影响

Effects of cloprostol sodium and carbetocin on parturition of sows

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分组 Treatment	样本量 Sample size	胎次 Parity	注射至分娩时间间隔 Injection-farrowing interval/h	白天产仔比例 Daytime farrowing ratio/%	产仔持续时间 Farrowing duration/ min	总产仔数 Total number born	活产仔数 Number born alive	仔猪死亡率 Piglet mortality/%
空白对照组 Control group	81	3.76± 1.73	27.10± 21.36 a	56.79 (47/81)	272± 153 a	12.83± 2.06	11.66± 2.82	4.39 (44/1 003)
2 mL氯前列醇钠 (后海穴注射)	70	3.43± 2.05	22.52± 10.85 b	88.57 (62/70)	236± 102 ab	12.85± 2.36	11.42± 2.38	4.68 (42/900)
2 mL Cloprostenol sodium (Houhai acupoint injection group)
2 mL卡贝缩宫素 (后海穴注射)	67	3.27± 1.86	10.82± 4.53 b	85.07 (57/67)	223± 86 ab	12.49± 2.23	11.70± 2.55	4.90 (41/837)
2 mL CBT (Houhai acupoint injection group)
2 mL氯前列醇钠 +2 mL CBT	64	3.55± 2.11	20.42± 6.47 b	95.31 (61/64)	205± 77 bc	12.78± 2.16	11.13± 2.57	4.77 (39/818)
2 mLCloprostenol sodium+ 2 mL CBT (Houhai acupoint injection group)

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