Research advances in non-structural protein 2 of porcine reproductive and respiratory syndrome virus

doi:10.3969/j.issn.1004-1524.2018.02.23

›› 2018, Vol. 30 ›› Issue (2): 350-356.DOI: 10.3969/j.issn.1004-1524.2018.02.23

• Review • Previous Articles

Research advances in non-structural protein 2 of porcine reproductive and respiratory syndrome virus

ZHAO Jun¹, XU Zhiwen^{1, 2}, ZHU Ling^{1, 2, *}

1. College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China;
2. Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China

Received:2017-06-05 Online:2018-02-20 Published:2018-02-11

Abstract

Abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent of porcine reproductive and respiratory syndrome (PRRS). It is an infectious disease that causes complex systemic disease of swine, which most notably affects the respiratory of infected piglets and reproductive systems of infected sows. PRRS causes great economic losses to the swine industry worldwide. The depth study of PRRSV related pathogenic mechanism will lay an important theoretical foundation for the prevention and control of the disease. The non-structural protein 2 (Nsp2) is always the hotspot of these PRRSV studies. This review discussed the correlation between Nsp2 and genetic variations, viral pathogenicity, viral replication, immunological functions, recombinant vaccine and molecular signature. Nsp2 gene played an important role in the differential diagnosis of vaccine strains.

Key words: PRRSV, Nsp2, genetic variation, virus replication, molecular signature

CLC Number:

S855.3

ZHAO Jun, XU Zhiwen, ZHU Ling. Research advances in non-structural protein 2 of porcine reproductive and respiratory syndrome virus[J]. , 2018, 30(2): 350-356.

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Research advances in non-structural protein 2 of porcine reproductive and respiratory syndrome virus

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