Effect of chicken-derived compound probiotics on immunoglobulin and toll-like receptor pathway of white feather broilers

doi:10.3969/j.issn.1004-1524.2020.09.09

›› 2020, Vol. 32 ›› Issue (9): 1609-1614.DOI: 10.3969/j.issn.1004-1524.2020.09.09

• Animal Science • Previous Articles Next Articles

Effect of chicken-derived compound probiotics on immunoglobulin and toll-like receptor pathway of white feather broilers

GUI Xueer¹, WANG Zhi¹, LI Siting¹, HE Mengchu¹, ZHU Jie², FENG Shibin¹, WU Jinjie^1,*

1. College of Animal Science and Technology, Anhui Agricultural University, Hefei 230061, China;
2. Xuancheng Muzi Poultry Cooperative, Xuancheng 242000, China

Received:2019-12-30 Online:2020-09-25 Published:2020-10-10

Abstract

Abstract: To investigate the effects of probiotics on serum immunoglobulin and intestinal Toll-like receptor pathway in White feather broiler, one hundred and eighty 28-day-old white feather hybrid broilers were randomly divided into group I (basic diet), group II (basic diet adding 10¹¹ CFU·kg^-1 probiotics) and group III ((basic die adding 2×10¹¹ CFU·kg^-1 probiotics), with 3 repeats in each group and 20 broilers in each repeat. The experimental period was 21 d. The results showed that, compared with group A, the serum IgG and IgM levels in group B and group C increased significantly (P<0.05). The protein expression of TLR2, TLR4, Myd88, TRAF-6, AP-1 and their relative expression of mRNA in group B and group C were significantly (P<0.05) increased. Compared with group B, the serum IgG, IgM and IgA levels in group C were no significant difference (P>0.05). The protein expression of TLR4 and MyD88 in group C were significantly (P<0.05) increased, and the relative expression of MyD88 mRNA was significantly (P<0.05) increased. Feeding probiotics can improve the serum IgG and IgM levels of white feather broilers, and regulate the immune function of broiler intestine effectively through toll like receptor pathway.

Key words: lactic acid bacteria, Bacillus subtilis, white feather broiler, immunoglobulin, toll-like receptor pathway

CLC Number:

S831

GUI Xueer, WANG Zhi, LI Siting, HE Mengchu, ZHU Jie, FENG Shibin, WU Jinjie. Effect of chicken-derived compound probiotics on immunoglobulin and toll-like receptor pathway of white feather broilers[J]. , 2020, 32(9): 1609-1614.

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Effect of chicken-derived compound probiotics on immunoglobulin and toll-like receptor pathway of white feather broilers

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