Abstract: The primary goal of this research was to optimize microwave solid\|state synthesis by which the acete peptide chelating calcium was prepared with response surface analysis. The results showed that the best optimal condition was as follows: the mass ratio of acete peptide and calcium lactate was 25∶1， microwave power 420 W， chelation time 73 s， in which the chelation percent of Ca2+ was about 8209%.

Key words: microwave solid\, state synthesis, acete peptide chelating calcium, response surface analysis （RSA）