Abstract: An aflatoxin B1 （AFB1） poisoning model was firstly established in the present study. Ducks were divided into control group， Na2SeO3 group， model group， low/medium/high\|dose compound Chai Qin particles group. 7， 14， 21 d after treatment， liver tissues of ducks were taken to detect of the activities of CYP3A4， CYP1A2 and CYP2E1. Compared with model group， activities of CYP3A4， CYP1A2 and CYP2E1 in liver after 7， 14 d decreased significantly in three compound Chai Qin particles groups regardless of doses. Then， the activities of CYP3A4， CYP1A2 and CYP2E1 increased in these three groups after 21 d. But， there were no significant differences in the activities of CYP3A4， CYP1A2 and CYP2E1 among model group and compound Chai Qin particles groups. It was suggested that compound Chai Qin particles could effectively decrease activities of CYP1A2， CYP2E1 and CYP3A4 in the early treatment of aflatoxicosis by decreasing the activation of AFB1， which could reduce the chemical liver injury， and the increasing activities of CYP450 after 21 d treatment with compound Chai Qin particles might be caused by the increasing demand of CYP450 to metabolize AFB1.

Key words: cytochrome CYP1A2, cytochrome CYP3A4, cytochrome CYP2E1, compound Chai Qin particles, aflatoxin B1