Bacteriostatic effect of medium-chain fatty acids and their esters on pathogenic bacteria

doi:10.3969/j.issn.1004-1524.2021.09.05

Acta Agriculturae Zhejiangensis ›› 2021, Vol. 33 ›› Issue (9): 1611-1616.DOI: 10.3969/j.issn.1004-1524.2021.09.05

• Animal Science • Previous Articles Next Articles

Bacteriostatic effect of medium-chain fatty acids and their esters on pathogenic bacteria

TANG Jianing¹(), WANG Yongxia¹, LIU Jinsong², ZENG Xinfu², YANG Caimei²^,^*()

1. College of Animal Science And Technology, Zhejiang A & F University, Hangzhou 311300, China
2. Zhejiang Huijia Bio-Technology Co., Ltd., Anji 311107, China

Received:2020-08-14 Online:2021-09-25 Published:2021-10-09
Contact: YANG Caimei

Abstract

Abstract:

Medium-chain fatty acid glycerides have become a new hot spot in the research of antibiotic substitutes. The purpose of this study was to investigate the bacteriostatic effects of lauric acid, glycerol monooctanoate, glycerol monolaurate and glycerol octanoate on Escherichia coli, Staphylococcus aureus, Salmonella enteritidis and Salmonella pullorum. The results showed that four medium-chain fatty acid glycerides had certain inhibitory effects on four kinds of pathogenic bacteria. Among them, the effects of lauric acid, glycerol monolaurate and glycerol monooctanoate on four kinds of pathogenic bacteria increased with time.

Key words: medium chain fatty acids, Escherichia coli, Salmonella enteritidis, Staphylococcus aureus, Salmonella pullorum, bacteriostatic effect

CLC Number:

S859

TANG Jianing, WANG Yongxia, LIU Jinsong, ZENG Xinfu, YANG Caimei. Bacteriostatic effect of medium-chain fatty acids and their esters on pathogenic bacteria[J]. Acta Agriculturae Zhejiangensis, 2021, 33(9): 1611-1616.

Figures/Tables 4

Fig.1 Antibacterial effects of different medium-chain fatty acid glycerides on Escherichia coli The values with different letters in the same time showed significant difference (P<0.05). The same as below.

Fig.2 Antibacterial effects of different medium-chain fatty acid glycerides on Staphylococcus aureus

Fig.3 Antibacterial effect of different medium-chain fatty acid glycerides on Salmonella enteritidis

Fig.4 Antibacterial effect of different medium-chain fatty acid glycerides on Salmonella pullorum

References 20

[1]	LOUNG F S, SILALAHI J, SURYANTO D. Antibacterial activity of enzymatic hydrolyzed of virgin coconut oil and palm kernel oil against Staphylococcus aureus, Salmonella thypi and Escherichia coli[J]. International Journal of Pharmtech Research, 2014, 6(2):628-633.
[2]	张立伟, 石玉祥, 张永英, 等. 鸡源大肠杆菌毒力基因检测及分子流行特征[J]. 微生物学报, 2020, 60(11):2498-2510.
	ZHANG L W, SHI Y X, ZHANG Y Y, et al. Analysis of virulence genes and molecular characteristics of chicken-derived Escherichia coli[J]. Acta Microbiologica Sinica, 2020, 60(11):2498-2510.(in Chinese with English abstract)
[3]	STEFANI S, CHUNG D R, LINDSAY J A, et al. Meticillin-resistant Staphylococcus aureus(MRSA): global epidemiology and harmonisation of typing methods[J]. International Journal of Antimicrobial Agents, 2012, 39(4):273-282. DOI URL
[4]	XIE S, LI Y C, ZHAO S Y, et al. Salmonella infection induced intestinal crypt hyperplasia through Wnt/β-catenin pathway in chicken[J]. Research in Veterinary Science, 2020, 130:179-183. DOI URL
[5]	孙晓鸣. 鸡白痢诊断与治疗[J]. 畜牧兽医科学(电子版), 2020(2):114-115.
	SUN X M. Diagnosis and treatment of chicken pullorum[J]. Graziery Veterinary Sciences (Electronic Version), 2020(2):114-115.(in Chinese)
[6]	何凤琴, 刘宏山. 中链脂肪酸甘油酯在动物生产中的研究与应用[J]. 畜牧与兽医, 2018, 50(7):137-140.
	HE F Q, LIU H S. Research on application of medium-chain triglyceride in animal production[J]. Animal Husbandry & Veterinary Medicine, 2018, 50(7):137-140.(in Chinese with English abstract)
[7]	LEE H F, CHIANG S H. Energy value of medium-chain triglycerides and their efficacy in improving survival of neonatal pigs1[J]. Journal of Animal Science, 1994, 72(1):133-138. DOI URL
[8]	LI Q S, ESTES J D, SCHLIEVERT P M, et al. Glycerol monolaurate prevents mucosal SIV transmission[J]. Nature, 2009, 458(7241):1034-1038. DOI URL
[9]	杨博, 马永喜, 沈水宝. 脂类在饲料行业中应用的新思考[J]. 动物营养学报, 2019, 31(11):4901-4908.
	YANG B, MA Y X, SHEN S B. Rethinking of using lipids in feed industry[J]. Chinese Journal of Animal Nutrition, 2019, 31(11):4901-4908.(in Chinese with English abstract)
[10]	刘梦芸, 陈晓倩, 赵豪斌, 等. 饲粮中添加单月桂酸甘油酯对肉鸡生长性能、消化能力及鸡肉营养品质的影响[J]. 食品科学, 2018, 39(15):67-71.
	LIU M Y, CHEN X Q, ZHAO H B, et al. Effect of dietary supplementation with glycerol monolaurate on growth performance, digestive ability and chicken nutritional components of broilers[J]. Food Science, 2018, 39(15):67-71.(in Chinese with English abstract)
[11]	刘梦芸, 王建莉, 冯凤琴. 饲粮添加单月桂酸甘油酯对蛋鸡生产性能、蛋品质、血清生化指标、免疫器官指数和腹脂形态的影响[J]. 中国家禽, 2017, 39(17):24-30.
	LIU M Y, WANG J L, FENG F Q. Effects of glycerol monolaurate on production performance, egg quality, serum parameters, immune organ index and abdominal fat morphology of laying hens[J]. China Poultry, 2017, 39(17):24-30.(in Chinese with English abstract)
[12]	薛永强, 黄志威, 雷志伟, 等. 中短链脂肪酸在无抗饲料中的应用[J]. 饲料研究, 2020(3):133-136.
	XUE Y Q, HUANG Z W, LEI Z W, et al. Application of short-medium chain fatty acids in non-resistant feed[J]. Feed Research, 2020(3):133-136.(in Chinese with English abstract)
[13]	刁慧, 张锦秀, 张纯, 等. 中链脂肪酸在仔猪营养中的生理功能研究进展[J]. 中国畜牧杂志, 2020, 56(2):33-38.
	DIAO H, ZHANG J X, ZHANG C, et al. Advances in physiological function of medium-chain fatty acids in piglet nutrition[J]. Chinese Journal of Animal Science, 2020, 56(2):33-38.(in Chinese with English abstract)
[14]	KITAHARA T, AOYAMA Y, HIRAKATA Y, et al. In vitro activity of lauric acid or myristylamine in combination with six antimicrobial agents against methicillin-resistant Staphylococcus aureus(MRSA)[J]. International Journal of Antimicrobial Agents, 2006, 27(1):51-57. DOI URL
[15]	YEN H C, LAI W K, LIN C S, et al. Medium-chain triglyceride as an alternative of in-feed colistin sulfate to improve growth performance and intestinal microbial environment in newly weaned pigs[J]. Animal Science Journal, 2015, 86(1):99-104. DOI URL
[16]	赵存洋. 单月桂酸甘油酯的抑菌性能及机理研究[D]. 南昌: 南昌大学, 2013.
	ZHAO C Y. Study on antibacterial properties of monolaurin and its mechanism[D]. Nanchang: Nanchang University, 2013.(in Chinese with English abstract)
[17]	LIEBERMAN S, ENIG M G, PREUSS H G. A review of monolaurin and lauric acid: natural virucidal and bactericidal agents[J]. Alternative and Complementary Therapies, 2006, 12(6):310-314. DOI URL
[18]	FORTUOSO B F, DOS REIS J H, GEBERT R R, et al. Glycerol monolaurate in the diet of broiler chickens replacing conventional antimicrobials: Impact on health, performance and meat quality[J]. Microbial Pathogenesis, 2019, 129:161-167. DOI URL
[19]	KIMSEY H R, ADAMS D M, KABARA J J. Increased inactivation of bacterial spores at high temperatures in the presence of monoglycerides2[J]. Journal of Food Safety, 1981, 3(2):69-82. DOI URL
[20]	张佩华, 梅子, 傅玉颖, 等. 食品级单辛酸甘油酯微乳液的抑菌研究[J]. 食品工业科技, 2013, 34(13):136-138.
	ZHANG P H, MEI Z, FU Y Y, et al. Antimicrobial activity evaluation of food grade glycerol mono-octanoate microemulsion[J]. Science and Technology of Food Industry, 2013, 34(13):136-138.(in Chinese with English abstract)

Bacteriostatic effect of medium-chain fatty acids and their esters on pathogenic bacteria

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