Effects of cloprostol sodium and carbetocin on parturition of sows

doi:10.3969/j.issn.1004-1524.2022.05.05

Acta Agriculturae Zhejiangensis ›› 2022, Vol. 34 ›› Issue (5): 915-922.DOI: 10.3969/j.issn.1004-1524.2022.05.05

• Animal Science • Previous Articles Next Articles

Effects of cloprostol sodium and carbetocin on parturition of sows

ZHANG Liang(), CHAI Jie, PAN Hongmei(), GUO Zongyi

Chongqing Academic of Animal Science, Chongqing 402460, China

Received:2020-11-13 Online:2022-05-25 Published:2022-06-06
Contact: PAN Hongmei

Abstract

Abstract:

As a synthetic prostaglandin analog, cloprostol sodium is widely used to induce delivery in various livestock. Carbetocin (CBT) is an oxytocin-like molecule with long-acting properties which targets the same receptors on the myometrium as oxytocin. It is currently considered to be a substitute for oxytocin in the sows to contract the uterus to initiate delivery. The first trial mainly studied the injection site and dosage of cloprostol sodium. The sows were randomly divided into natural delivery group (n=74), 2 mL intramuscular injection group (n=52), 2 mL Houhai acupoint injection group (n=63) and 1 mL Houhai acupoint injection group (n=57). The results of the study showed that the sows in the 2 mL Houhai acupoint injection group showed more synchronized farrowing time, with the shortest farrowing duration (228 min) and the highest daytime delivery rate (90.48%). It was indicated that the sows’ farrowing duration can be shortened and the daytime delivery rate of sows can be improved to a certain extent by adjusting the injection time, dosage and location of sodium cloprostol. The second trial mainly studied the effect of carbetocin (CBT) in combination with cloprostol sodium. The sows were randomly divided into natural delivery group (n=81), cloprostol sodium injection group (n=70), and CBT injection group (n=67), cloprostol sodium+CBT injection group (n=64). The results of the study showed that the combined application of cloprostol sodium and carbetocin could shorten the farrowing duration of sows (205 min), and significantly increased the daytime delivery rate in the working hours (95.31%).

Key words: sows, induced parturition, carbetocin, cloprostol sodium, daytime delivery

CLC Number:

S828

ZHANG Liang, CHAI Jie, PAN Hongmei, GUO Zongyi. Effects of cloprostol sodium and carbetocin on parturition of sows[J]. Acta Agriculturae Zhejiangensis, 2022, 34(5): 915-922.

Figures/Tables 4

References 20

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季节Season	日出时间Sunrise time	日落时间Sun setting time	昼长Daylength/h	白天时间Daytime
春季Spring	6:07~6:59	19:08~19:40	12.85~0.70	6:30—19:30
夏季Summer	5:56~6:22	19:45~19:53	13.67~0.38	6:00—20:00
秋季Autumn	6:44~7:18	18:05~18.55	11.50~0.70	7:00—18:30
冬季Winter	7:36~7:52	18:04~18:40	10.63~0.38	8:00—18:30

季节Season	日出时间Sunrise time	日落时间Sun setting time	昼长Daylength/h	白天时间Daytime
春季Spring	6:07~6:59	19:08~19:40	12.85~0.70	6:30—19:30
夏季Summer	5:56~6:22	19:45~19:53	13.67~0.38	6:00—20:00
秋季Autumn	6:44~7:18	18:05~18.55	11.50~0.70	7:00—18:30
冬季Winter	7:36~7:52	18:04~18:40	10.63~0.38	8:00—18:30

分组 Treatment	样本量 Sample size	胎次 Parity	注射至分娩时间间隔 Injection-farrowing interval/h	白天产仔比例 Daytime farrowing ratio/%	产仔持续时间 Farrowing duration/min	总产仔数 Total number born	活产仔数 Number born alive
空白对照组	74	4.88±2.56	28.90±22.10	55.41(41/74)	262±144	11.20±2.45	10.52±2.38
Control group
2 mL氯前列醇钠组 (肌肉注射)	52	4.67± 2.43	24.23±13.67	86.54(45/52)	254±137	11.54±2.04	10.30±2.61
2 mL Cloprostenol sodium (intramuscular injection group)
2 mL氯前列醇钠 (后海穴注射)	63	4.55±2.76	23.88±7.53	90.48(57/63)	228±101	11.29±2.26	10.60±2.82
2 mL Cloprostenol sodium (Houhai acupoint injection group)
1 mL氯前列醇钠 (后海穴注射)	57	4.78±2.86	23.42±10.28	78.95(45/57)	237±109	11.35±2.53	10.40±2.54
1 mL Cloprostenol sodium (Houhai acupoint injection group)

分组 Treatment	样本量 Sample size	胎次 Parity	注射至分娩时间间隔 Injection-farrowing interval/h	白天产仔比例 Daytime farrowing ratio/%	产仔持续时间 Farrowing duration/min	总产仔数 Total number born	活产仔数 Number born alive
空白对照组	74	4.88±2.56	28.90±22.10	55.41(41/74)	262±144	11.20±2.45	10.52±2.38
Control group
2 mL氯前列醇钠组 (肌肉注射)	52	4.67± 2.43	24.23±13.67	86.54(45/52)	254±137	11.54±2.04	10.30±2.61
2 mL Cloprostenol sodium (intramuscular injection group)
2 mL氯前列醇钠 (后海穴注射)	63	4.55±2.76	23.88±7.53	90.48(57/63)	228±101	11.29±2.26	10.60±2.82
2 mL Cloprostenol sodium (Houhai acupoint injection group)
1 mL氯前列醇钠 (后海穴注射)	57	4.78±2.86	23.42±10.28	78.95(45/57)	237±109	11.35±2.53	10.40±2.54
1 mL Cloprostenol sodium (Houhai acupoint injection group)

分组 Treatment	样本量 Sample size	胎次 Parity	注射至分娩时间间隔 Injection-farrowing interval/h	白天产仔比例 Daytime farrowing ratio/%	产仔持续时间 Farrowing duration/min
2 mL氯前列醇钠组(肌肉注射)	41	初产Primiparity	23.68±9.26	85.37(35/41)	274±32 a
2 mL Cloprostenol sodium (intramuscular injection group)
2 mL氯前列醇钠(后海穴注射)	131	经产Multiparity	23.94±11.36	85.50(112/131)	230±19 b
2 mL Cloprostenol sodium (Houhai acupoint injection group)

Effects of cloprostol sodium and carbetocin on parturition of sows

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分组 Treatment	样本量 Sample size	胎次 Parity	注射至分娩时间间隔 Injection-farrowing interval/h	白天产仔比例 Daytime farrowing ratio/%	产仔持续时间 Farrowing duration/ min	总产仔数 Total number born	活产仔数 Number born alive	仔猪死亡率 Piglet mortality/%
空白对照组 Control group	81	3.76± 1.73	27.10± 21.36 a	56.79 (47/81)	272± 153 a	12.83± 2.06	11.66± 2.82	4.39 (44/1 003)
2 mL氯前列醇钠 (后海穴注射)	70	3.43± 2.05	22.52± 10.85 b	88.57 (62/70)	236± 102 ab	12.85± 2.36	11.42± 2.38	4.68 (42/900)
2 mL Cloprostenol sodium (Houhai acupoint injection group)
2 mL卡贝缩宫素 (后海穴注射)	67	3.27± 1.86	10.82± 4.53 b	85.07 (57/67)	223± 86 ab	12.49± 2.23	11.70± 2.55	4.90 (41/837)
2 mL CBT (Houhai acupoint injection group)
2 mL氯前列醇钠 +2 mL CBT	64	3.55± 2.11	20.42± 6.47 b	95.31 (61/64)	205± 77 bc	12.78± 2.16	11.13± 2.57	4.77 (39/818)
2 mLCloprostenol sodium+ 2 mL CBT (Houhai acupoint injection group)

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