Research progress of biopesticides based on RNAi

doi:10.3969/j.issn.1004-1524.20230563

Acta Agriculturae Zhejiangensis ›› 2024, Vol. 36 ›› Issue (4): 968-977.DOI: 10.3969/j.issn.1004-1524.20230563

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Research progress of biopesticides based on RNAi

LU Ziqi¹^,²(), WANG Jing², ZHANG Zhen², WANG Jiaoyu²^,^*(), SUN Guocang², LIN Fucheng²

1. College of Advanced Agricultural Sciences, Zhejiang A & F University, Hangzhou 311300, China
2. State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Key Laboratory of Agricultural Microbiome, Ministry of Agriculture and Rural Affairs, Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China

Received:2023-07-27 Online:2024-04-25 Published:2024-04-29
Contact: WANG Jiaoyu

Abstract

Abstract:

The extensive use of chemical pesticides has brought about a series of problems, such as pest resistance, environmental pollution and agricultural product safety. The new sustainable plant protection strategy has become an inevitable requirement for the green development of agriculture. In recent years, the application potential of RNAi in plant disease and pest control has received more and more attention, and the research and development of biological pesticides based on RNAi (namely nucleic acid pesticides) is becoming more and more rapid. Nucleic acid pesticides are based on spray-induced gene silencing (SIGS). Exogenous application of dsRNA targeting target pathogens or pests can trigger RNAi to inhibit pathogens or pests and achieve specific control of target diseases and pests. Due to the advantages of target specificity, environmental friendliness and low resistance of nucleic acid pesticides, the research and development process of RNAi are accelerating. Therefore, nucleic acid pesticides are expected to become an important supplement or substitute for chemical pesticides. In this paper, the mechanism of action, research progress, product development and application status, risks in the process of commercialization and use, and problems that need to be noted of nucleic acid pesticides are reviewed, in order to provide reference for related research.

Key words: nucleic acid pesticides, RNAi, dsRNA, disease and pest control

CLC Number:

LU Ziqi, WANG Jing, ZHANG Zhen, WANG Jiaoyu, SUN Guocang, LIN Fucheng. Research progress of biopesticides based on RNAi[J]. Acta Agriculturae Zhejiangensis, 2024, 36(4): 968-977.

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Research progress of biopesticides based on RNAi

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