Abstract: In recent years, brominated flame retardants (BFRs), one of the most widely used flame retardants in the polymer and the fabric widely are used in various consumers and industrial products. BFRs are persistent organic pollutants which has been widespread in the environment and has attracted wide international attention. As the use of BFRs increasing year by year, BFRs have been widely detected and showed varying degrees of toxic effects on aquatic animals, birds and mammals, the breadth of its distribution, refractory and uncertainty in human health has attracted peoples attention. Based on results of animal toxicology studies abroad, the article discussed the effects of BFRs and their metabolites on endocrine disrupting activity of different animals, mainly on the level of thyroid hormone, estrogen, androgen levels and the development of animal nervous systems, and provided a theoretical basis for evaluation of BFRs on the impact of animal and human health.

Key words: brominated flame retardants (BFRs), endocrine disruption, thyroid hormone disruption, gonadal hormone disruption