Abstract: In the year of 2012, the state council of the People's Republic of China put forward the “National Plan for Prevention and Control of Long-term Animal Diseases (2012-2020)”, which requires the gradual control, eradication and elimination of 16 animal diseases. Based on this, this paper used the survey data of 297 chicken farms in China, in order to analyze the effect of the disease purifying on the breeding of offspring of chicken farms using random effects model. The results showed that the daily highest egg laying rate, hatching egg pass rate, hatching egg fertility rate and fertile egg hatching rate of purified chicken farms were1.091%, 1.090%, 0.892%, 0.528% higher than those of unpurified chicken farms respectively. Compared with the difference between the index of breeding of offspring between the purified chicken farms and the unpurified chicken farms, the differences caused by purified different disease types were small. Increasing vaccine expense, reducing the use of veterinary drugs, and rationally setting up the number of technicians can effectively improve the breeding ability of the offspring of the flock. Using enclosed chicken house, non-cage housing method, non-autotrophic breeding method and bulk marketing could improve the breeding ability of the offspring of the chicken farms to some extent. Among the seven regions in the country, the chickens in north China had the strongest breeding offspring ability. The government should step up publicity on the disease eradication, and actively organize training and communication of disease eradication. While carrying out the disease eradication, the chicken farms need to pay attention to the vaccine immunization work, minimize the use of veterinary drugs, and effectively employ technicians.

Key words: disease eradication, scale farming, offspring breeding, chicken farm