Pharmacokinetics of enrofloxacin in largemouth bass (Micropterus salmoides)

doi:10.3969/j.issn.1004-1524.2018.09.06

›› 2018, Vol. 30 ›› Issue (9): 1482-1488.DOI: 10.3969/j.issn.1004-1524.2018.09.06

• Animal Science • Previous Articles Next Articles

Pharmacokinetics of enrofloxacin in largemouth bass (Micropterus salmoides)

HE Xin¹, WANG Yang^{2, *}, BEI Yijiang²

1. Testing Center, Hangzhou Academy of Agricultural Sciences, Hangzhou 310024, China;
2. Zhejiang Fishery Technology Extension Center, Hangzhou 310012, China

Received:2017-12-19 Online:2018-09-25 Published:2018-10-15
Contact: 王扬,E-mail: 1752315020@qq.com
Supported by:
浙江省水产品质量安全技术支撑团队(QS2016012); 杭州市农科院创新基金(2018HNCX-06); 浙江省农业新品种选育重大科技专项重点研发计划(2016C02055-3)

Abstract

Abstract: To investigate the metabolic rate of enrofloxacin in largemouth bass (Micropterus salmoides) and facilitate dosage decisions, the pharmacokinetics of enrofloxacin in largemouth bass were studied after 5 d fed with 30 mg·kg^-1 (oral doses, based on body weight) enrofloxacin under (25±2) ℃. The concentrations of enrofloxacin in largemouth bass were determined by high performance liquid chromatography, and the drug-time curves were calculated. It was shown that the peak times of enrofloxacin in blood, muscle and liver were all 4 h under the experiment conditions. The absorption half lives of enrofloxacin in blood, muscle and liver were 0.998, 2.176, 1.892 h, respectively, and elimination half lives were 8.494, 23.84, 37.53 h, respectively. The area under drug concentration-time curves were 132.23 μg·mL^-1·h in plasma and 273.50, 247.12 μg·g^-1·h, respectively, in muscle and liver. Recommended withdrawal period of enrofloxacin in largemouth bass was 15 d under 25 ℃.

Key words: enrofloxacin, largemouth bass, pharmacokinetics

CLC Number:

S948

HE Xin, WANG Yang, BEI Yijiang. Pharmacokinetics of enrofloxacin in largemouth bass (Micropterus salmoides)[J]. , 2018, 30(9): 1482-1488.

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Pharmacokinetics of enrofloxacin in largemouth bass (Micropterus salmoides)

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