Abstract: Bombyx mori is the model organism of lepidopteran insects. In recent years，proteomic research of essential organs in silkworm such as embryo，silk gland，hemolymph，midgut has made considerable progress，providing abundance of information for revealing the related phenomenon and characteristics and its formation mechanism，which were reviewed in this paper. Moreover，the future developmental trends and the application prospects of silkworm proteomics were discussed.

Key words: Bombyx mori, proteomics, progress