Abstract: In order to assess the infected risk of newcastle disease virus(NDV) and avian influenza virus(AIV) of workers occupationally exposed to poultry, a survey was conducted among workers in large-scale poultry farms and poultry products processing factory. Serum samples of 21 poultry workers and 20 workers in poultry product processing factory were collected and tested for NDV, H5N1 and H9N2 neutralizing antibodies by microneutralization assay. All participants showed negative for H5N1 and H9N2 neutralizing antibodies. Seven poultry workers and one worker of poultry products processing factory were tested positive for NDV neutralizing antibodies. The results showed that the newcastle disease virus could infect human, and there's little possibility of AIV (H5N1 and H9N2 subtype)transmission among people with occupational poultry exposure. Despite no serological evidence of AIV infection was identified among participants, continued surveilance for AIV in humans and further seroprevalence invesitigations were needed to assess the risk of aviantohuman transmission, in case that AIV continued to circulate and evolve among poultry．

Key words: people with occupational poultry exposure, avian influeza, newcastle disease, serological survey