浙江农业学报 ›› 2018, Vol. 30 ›› Issue (3): 507-520.DOI: 10.3969/j.issn.1004-1524.2018.03.21
• 综述 • 上一篇
戴超辉1, 冯海悦1, 吴圣龙1,2, 包文斌1,2,*
收稿日期:
2017-06-27
出版日期:
2018-03-20
发布日期:
2018-03-21
通讯作者:
*包文斌,E-mail: 作者简介:
戴超辉(1993—),女,湖南新化人,博士研究生,研究方向为猪抗病育种。E-mail:chdai1993@163.com
基金资助:
DAI Chaohui1, FENG Haiyue1, WU Shenglong1,2, BAO Wenbin1,2,*
Received:
2017-06-27
Online:
2018-03-20
Published:
2018-03-21
摘要: Toll样受体(toll like receptors, TLRs)作为模式识别受体,不仅能够对机体特异性配体进行识别,并通过多种信号传导通路(由髓样分化蛋白88或由β-干扰素TLR结构域衔接蛋白介导)启动信号传导继而引发特异性的免疫应答,同时还在一些由支原体、病毒、细菌等感染引起的免疫应答过程中发挥了重要的调控功能。因为其重要的免疫调控作用,Toll样受体家族已成为近些年研究的热点,对畜禽抗病育种工作也具有重要的科学意义和应用前景。文章综述了猪源TLRs的种类、功能、遗传变异以及介导的信号通路,并重点介绍了猪源TLRs在抗病育种中的应用,旨在为猪Toll样受体家族基因功能研究及有效遗传标记的筛选提供参考依据。
中图分类号:
戴超辉, 冯海悦, 吴圣龙, 包文斌. 猪源Toll样受体家族(TLRs)及其在抗病育种中的应用[J]. 浙江农业学报, 2018, 30(3): 507-520.
DAI Chaohui, FENG Haiyue, WU Shenglong, BAO Wenbin. Advances in porcine Toll-like receptor family (TLRs) and its application in resistance breeding[J]. , 2018, 30(3): 507-520.
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