猪繁殖与呼吸综合征病毒变异株自然感染病例的病理分析

›› 2010, Vol. 22 ›› Issue (4): 0-457.

• 论文 •

猪繁殖与呼吸综合征病毒变异株自然感染病例的病理分析

贺延玉¹,尚佑军^2,*

¹甘肃农业大学研究测试中心,甘肃兰州 730070；²中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室农业部畜禽病毒学重点实验室国家口蹄疫参考实验室,甘肃兰州 730046

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-07-25 发布日期:2010-07-25

Pathology study on the natural infection by a variant strain of Porcine reproductive and respiratory syndrome virus

HE Yan-yu;SHANG You-jun;*

¹ Instrumental Research & Analysis Center, Gansu Agricultural University, Lanzhou 730070, China; ² Key Laboratory of Aminal Virology, Ministry of Agriculture/State Key Laboratory of Veterinary Etiological Biology/National Foot-and-Mouth Disease Virus Referenced Laboratory/Lanzhou Veterinary Research Institute, Chinese Academy of Agriculture Science, Lanzhou 730046, China

Received:1900-01-01 Revised:1900-01-01 Online:2010-07-25 Published:2010-07-25

摘要/Abstract

摘要： 为探讨猪繁殖与呼吸综合征病毒(Porcine reproductive and respiratory syndrome virus,PRRSV)变异毒株的致病特点,为其发病机制研究提供重要资料。对临床感染病例的肺脏、脾、肾、淋巴结等组织进行了显微和超微病理结构变化的观察。PRRSV变异毒株的病理损伤以间质性肺炎和全身性急性淋巴结炎为特征,伴有肝、脾、肾、心脏、胃和肠等器官的变性坏死；肺泡巨噬细胞、淋巴结及脾脏中的淋巴细胞和浆细胞均被不同程度的感染,并含有大量病毒包涵体。研究表明，PRRSV变异毒株的组织嗜性与中国典型毒株ch\|1a相比已有较大的改变,其感染会引起全身性免疫抑制。

关键词: 猪繁殖与呼吸综合征病毒, 变异株, 病理学

Abstract: In order to explore the pathological characters and pathogenesis of PRRSV variant strain, the microstructure and ultramicrostructure of lung, spleen, kidney and lymph node of piglets infected with PRRSV were studied. The results showed that the major pathological characters of PRRSV variant strain were interstitial pneumonia and adenolymphitis, accompanied by the degeneration and necrosis of liver, spleen, kidney, heart, stomach and intestine. Alveolar macrophages, lymph nodes and lymphocytes and plasma cells in spleen were infected with different degrees, where a large number of viral inclusion bodies were found. The results indicated that the tissue tropism of PRRSV variant strain, compared with the typical strain ch-1a in China, showed great changes and the infection could cause systemic immunosuppression．

Key words: Porcine reproductive and respiratory syndrome virus(PRRSV), variant strain, pathology

贺延玉;尚佑军;*. 猪繁殖与呼吸综合征病毒变异株自然感染病例的病理分析[J]. , 2010, 22(4): 0-457.

HE Yan-yu;SHANG You-jun;*. Pathology study on the natural infection by a variant strain of Porcine reproductive and respiratory syndrome virus[J]. , 2010, 22(4): 0-457.

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猪繁殖与呼吸综合征病毒变异株自然感染病例的病理分析

Pathology study on the natural infection by a variant strain of Porcine reproductive and respiratory syndrome virus

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