猪繁殖与呼吸综合征病毒非结构蛋白2研究进展

doi:10.3969/j.issn.1004-1524.2018.02.23

浙江农业学报 ›› 2018, Vol. 30 ›› Issue (2): 350-356.DOI: 10.3969/j.issn.1004-1524.2018.02.23

• 综述 • 上一篇

猪繁殖与呼吸综合征病毒非结构蛋白2研究进展

赵军¹, 徐志文^{1, 2}, 朱玲^{1, 2, *}

1.四川农业大学动物医学院,四川成都 611130;
2.四川农业大学动物疫病与人类健康四川省重点实验室,四川成都 611130

收稿日期:2017-06-05 出版日期:2018-02-20 发布日期:2018-02-11
通讯作者: 朱玲,E-mail:abtczl72@126.com
作者简介:赵军(1991—),四川泸州人,硕士研究生,研究方向为动物传染病病原分子生物学。E-mail:zhaojunjoy@126.com
基金资助:
四川省科技支撑计划(2014NZ0043); 教育部“长江学者与创新团队发展计划” (IRT13083); 四川省“十三五”育种攻关项目(2016NYZ0052); 国家“十二五”科技支撑计划(2015BAD12B04-2.3)

Research advances in non-structural protein 2 of porcine reproductive and respiratory syndrome virus

ZHAO Jun¹, XU Zhiwen^{1, 2}, ZHU Ling^{1, 2, *}

1. College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China;
2. Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China

Received:2017-06-05 Online:2018-02-20 Published:2018-02-11

摘要/Abstract

摘要： 猪繁殖与呼吸综合征(porcine reproductive and respiratory syndrome,PRRS)是由PRRS病毒(PRRSV)引起的以母猪繁殖障碍和仔猪呼吸困难、病毒血症为典型症状的一种传染性疾病,给世界养猪业带来巨大的经济损失。深入研究PRRSV的相关致病机制可为该病防控奠定理论依据。在对PRRSV的研究中,非结构蛋白2(non-structural protein 2, Nsp2)一直是研究的热点,文章综述了Nsp2与遗传变异、病毒致病性、病毒复制、免疫调控和重组疫苗与分子标签等相关的研究进展。Nsp2基因序列在对疫苗毒株的鉴别诊断中发挥重要作用。

关键词: 猪繁殖与呼吸综合征病毒, 非结构蛋白2, 遗传变异, 病毒复制, 分子标签

Abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent of porcine reproductive and respiratory syndrome (PRRS). It is an infectious disease that causes complex systemic disease of swine, which most notably affects the respiratory of infected piglets and reproductive systems of infected sows. PRRS causes great economic losses to the swine industry worldwide. The depth study of PRRSV related pathogenic mechanism will lay an important theoretical foundation for the prevention and control of the disease. The non-structural protein 2 (Nsp2) is always the hotspot of these PRRSV studies. This review discussed the correlation between Nsp2 and genetic variations, viral pathogenicity, viral replication, immunological functions, recombinant vaccine and molecular signature. Nsp2 gene played an important role in the differential diagnosis of vaccine strains.

Key words: PRRSV, Nsp2, genetic variation, virus replication, molecular signature

中图分类号:

S855.3

赵军, 徐志文, 朱玲. 猪繁殖与呼吸综合征病毒非结构蛋白2研究进展[J]. 浙江农业学报, 2018, 30(2): 350-356.

ZHAO Jun, XU Zhiwen, ZHU Ling. Research advances in non-structural protein 2 of porcine reproductive and respiratory syndrome virus[J]. , 2018, 30(2): 350-356.

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猪繁殖与呼吸综合征病毒非结构蛋白2研究进展

Research advances in non-structural protein 2 of porcine reproductive and respiratory syndrome virus

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