Acta Agriculturae Zhejiangensis ›› 2021, Vol. 33 ›› Issue (9): 1770-1778.DOI: 10.3969/j.issn.1004-1524.2021.09.21

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Research progress of rapid detection of pesticides and veterinary drugs residues and heavy metal ions based on DNA G-quadruplex

SUN Liping1,2(), BAI Linlin2,3, GAN Yating1, CHEN Xueyun2,3, WANG Liu2, ZHANG Yiming1,*(), HE Kaiyu2,*(), XU Xiahong2   

  1. 1. College of Agriculture and Food Science, Zhejiang A&F University, Hangzhou 311300, China
    2. Institute of Quality Safety and Nutrition of Agri-Products, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China
    3. College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, China
  • Received:2020-08-10 Online:2021-09-25 Published:2021-10-09
  • Contact: ZHANG Yiming,HE Kaiyu

Abstract:

The conformation of DNA are diverse. In addition to the well-known double helix,a number of unconventional structures have been discovered and assembled, such as DNA triple helix,DNA hairpin structure,DNA i-motif, DNA G-quadruplex, and so on. These special DNA structures have some certain functions, for example, DNA G-quadruplexes can bind with hemin and significantly improve the intrinsic peroxidase activity of hemin. Besides this function, they also enhance the fluorescence intensity of some organic dyes. Further more, the formation and stability of G-quadruplexes are programmable and controllable, and they are excellent materials for the construction of chemosensors and biosensors. Taking some typical research works as examples, this paper summarized the application of G-quadruplexes in the rapid detection of pesticide residues, veterinary residues and heavy metals, and the prospective research and application are also discussed.

Key words: G-quadruplex, pesticides, veterinary drugs, heavy metal ions, colorimetric, fluorescence, rapid detection

CLC Number: