Abstract: The microwave\|assisted methods were used to extract polyphenol from Sargassum fusiforme. The extraction conditions were established in the single factor and orthogonal design. The results showed that the optimal conditions were as follows：alcohol density of 80% （V/V），microwave power of 600 W，temperature of 70 ℃，ratio of material to solvent of 1∶10 g·mL-1，and extraction time of 4 min，and the yield of polyphenol could reach 233%.

Key words: Sargassum fusiforme, microwave\|assisted extraction, polyphenols