Abstract: There are some bottlenecks in the development of immunochemical analysis for pesticides and mycotoxins, such as multi-residue analysis, the cost and availability of standard, and limit of sensitivity. However, the anti-idiotype antibodies (AId) have provided some new approaches to solve these problems. In this review, the principles of anti-idiotype antibodies were introduced and the special application advantages of AId in detection of small molecular contaminate in food were discussed. Current applications, restrictions and prospect of AId in these fields were also exemplified．

Key words: anti-idiotype antibodies, pesticides, mycotoxins, immunoassay