Analysis of correlation between polymorphism of IGF-1R gene and body size traits in egg quail

doi:10.3969/j.issn.1004-1524.2020.03.03

›› 2020, Vol. 32 ›› Issue (3): 398-405.DOI: 10.3969/j.issn.1004-1524.2020.03.03

• Animal Science • Previous Articles Next Articles

Analysis of correlation between polymorphism of IGF-1R gene and body size traits in egg quail

BAI Junyan^1,2, LU Junhao³, FU Xueyan¹, WU Xiaohong¹, YANG Youbing^1,2, LEI Ying^1,2, PANG Youzhi^1,2,*, LU Xiaoning¹, GONG Huirong¹, HU Luxing¹, LIU Hongtao¹, FAN Hongdeng¹, CAO Heng¹, SHI Kunpeng¹, CHEN Mengke¹, MA Yongkang¹

1.College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China;
2.Luoyang Key Laboratory of Animal Genetics and Breeding, Luoyang 471023, China;
3.College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China

Received:2019-06-15 Online:2020-03-25 Published:2020-04-03

Abstract

Abstract: Type 1 insulin-like growth factor receptor (IGF-1R) gene is the main effector of insulin-like growth factor (IGFs). It has important influence on the growth and development of the body. To investigate the correlation within IGF-1R and body size traits of egg quails, the polymorphism of IGF-1R gene was analyzed by direct sequencing of PCR products in Chinese yellow quail, Beijing white quail and Korean quail, and the correlation within the polymorphism of IGF-1R gene and body size traits of quail was analyzed. The results showed that two mutation sites of IGF-1R gene A57G and A72T were detected in three egg quail populations. A/G base mutation occurred at A57G site, including three genotypes of AA, AG and GG. A/T base mutation occurred at A72T site, including three genotypes of AA, AT and TT. The A57G locus of Chinese yellow quail had significant (P<0.05)effects on tibia length, sternal length and tibia circumference, A72T locus had significant (P<0.05) effects on body weight and sternal length, combination genotype AGAA had significant (P<0.05) effects on body weight, combination genotype AAAA had significant effects on tibia length, sternal length and tibia circumference (P<0.05). The A57G locus of Beijing white quail had significant effects on body weight, tibia length, body length and tibia circumference (P<0.05), A72T locus had significant (P<0.05) effect on sternal length, combination genotypes AAAA had significant (P<0.05) effects on body weight and sternal length, and combination genotypes AAAT, GGAA and GGAT had significant (P<0.05) effects on tibia length, the combined genotype GGAA had significant (P<0.05) effect on chest depth. The A57G locus of Korean quail had significant (P<0.05) effect on body weight, and the A72T locus had significant (P<0.05) effect on sternal length and tibia circumference, the combined genotype AGAA had significant (P<0.05) effect on body weight, and the combined genotype AGAT had significant (P<0.05) effect on tibia length and chest width. Therefore, the IGF-1R gene could be used as a candidate gene for molecular marker-assisted selection of body size traits in egg quails.

Key words: egg quail, type 1 insulin-like growth factor receptor (IGF-1R) gene, polymorphism, body size traits, correlation analysis

CLC Number:

S839

BAI Junyan, LU Junhao, FU Xueyan, WU Xiaohong, YANG Youbing, LEI Ying, PANG Youzhi, LU Xiaoning, GONG Huirong, HU Luxing, LIU Hongtao, FAN Hongdeng, CAO Heng, SHI Kunpeng, CHEN Mengke, MA Yongkang. Analysis of correlation between polymorphism of IGF-1R gene and body size traits in egg quail[J]. , 2020, 32(3): 398-405.

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Analysis of correlation between polymorphism of IGF-1R gene and body size traits in egg quail

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