Effects of high-purine diet on blood lipid changes and pathological lesion in golden hamsters

doi:10.3969/j.issn.1004-1524.20240238

Acta Agriculturae Zhejiangensis ›› 2025, Vol. 37 ›› Issue (1): 24-31.DOI: 10.3969/j.issn.1004-1524.20240238

• Animal Science • Previous Articles Next Articles

Effects of high-purine diet on blood lipid changes and pathological lesion in golden hamsters

HE Liang¹(), LI Qingxiangzi¹, LI Rui²^,^*()

1. Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China
2. Institute of Agro-Product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China

Received:2024-03-14 Online:2025-01-25 Published:2025-02-14

Abstract

Abstract:

Increases of serum uric acid in golden hamsters were induced by the combination of high-purine diet and uric acid inhibitor potassium oxonate. Serum glucose, lipid changes and histopathological changes of kidney were detected, and the effects of high-purine diet on the changes of serum lipids and liver and kidney injury of golden hamster were investigated. The results showed that there was no significant change in the body weight and liver index of golden hamsters with high-purine diet, and the application of 12% yeast and 0.25% adenine combined with 2% potassium oxonate led to a significant increase in serum uric acid level, but the correlation between elevated serum uric acid and blood glucose and lipid metabolism disorders was not strong. Elevated uric acid leads to renal enlargement, significantly increased renal index, and renal pathological injury characteristic of typical hyperuricemia. The golden hamster with human lipid metabolism characteristics have good prospects for the development of animal models of hyperuricemia.

Key words: golden hamster, uric acid, lipid, kidney injury

CLC Number:

S859

HE Liang, LI Qingxiangzi, LI Rui. Effects of high-purine diet on blood lipid changes and pathological lesion in golden hamsters[J]. Acta Agriculturae Zhejiangensis, 2025, 37(1): 24-31.

Figures/Tables 6

References 22

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组别 Group	体重 Body weight/g	肾脏质量 Kidney weight/g	肝脏质量 Liver weight/g	肾脏指数 Kidney index/%	肝脏指数 Liver index/%
NC	155.0±10.4	0.9±0.1	4.3±0.4	0.61±0.04	2.78±0.21
NB	149.0±14.1	1.0±0.1	3.8±0.5	0.67±0.02	2.55±0.18
ND	153.5±17.0	1.3±0.1	4.2±0.7	0.85±0.08	2.70±0.20
NF	147.8±11.9	1.2±0.6	4.0±0.3	0.81±0.43	2.72±0.17
NE	145.5±14.5	1.7±0.2^*	4.0±0.5	1.17±0.14^*	2.73±0.12

组别 Group	体重 Body weight/g	肾脏质量 Kidney weight/g	肝脏质量 Liver weight/g	肾脏指数 Kidney index/%	肝脏指数 Liver index/%
NC	155.0±10.4	0.9±0.1	4.3±0.4	0.61±0.04	2.78±0.21
NB	149.0±14.1	1.0±0.1	3.8±0.5	0.67±0.02	2.55±0.18
ND	153.5±17.0	1.3±0.1	4.2±0.7	0.85±0.08	2.70±0.20
NF	147.8±11.9	1.2±0.6	4.0±0.3	0.81±0.43	2.72±0.17
NE	145.5±14.5	1.7±0.2^*	4.0±0.5	1.17±0.14^*	2.73±0.12

组别 Group	GLU	TG	CHO	HDL	LDL
NC	8.5±1.4	1.3±0.2	3.3±0.6	2.2±0.4	1.0±0.3
NB	8.9±3.0	1.3±0.6	2.7±0.4	2.0±0.3	0.8±0.1
ND	8.6±2.4	1.8±0.6	3.2±0.7	2.4±0.4	1.3±0.3
NF	8.0±3.3	1.6±0.6	2.7±0.8	2.5±0.4	0.9±0.3
NE	8.9±3.2	1.2±0.5	3.0±0.6	2.5±0.4	1.2±0.3

组别 Group	GLU	TG	CHO	HDL	LDL
NC	8.5±1.4	1.3±0.2	3.3±0.6	2.2±0.4	1.0±0.3
NB	8.9±3.0	1.3±0.6	2.7±0.4	2.0±0.3	0.8±0.1
ND	8.6±2.4	1.8±0.6	3.2±0.7	2.4±0.4	1.3±0.3
NF	8.0±3.3	1.6±0.6	2.7±0.8	2.5±0.4	0.9±0.3
NE	8.9±3.2	1.2±0.5	3.0±0.6	2.5±0.4	1.2±0.3

组别 Group	BUN/ (mg·dL^-1)	Cre/ (μmol·L^-1)	ALT/ (U·L^-1)	AST/ (U·L^-1)	ALP/ (U·L^-1)	TP/ (g·L^-1)	ALB/ (g·L^-1)
NC	16.0±2.2	35.1±6.2	98.6±31.5	78.3±13.9	144.8±5.5	73.9±4.8	42.2±1.4
NB	16.0±1.6	33.7±3.6	105.7±17.9	94.8±42.3	135.8±12.4	67.0±6.2	41.4±2.2
ND	17.1±1.7	39.6±4.4	113.2±22.8	151.9±31.3^*	178.3±23.4	70.5±7.5	42.1±3.4
NF	15.9±2.2	36.8±3.0	108.1±62.1	157.1±48.2^*	159.3±26.0	73.1±3.9	43.7±0.9
NE	18.2±1.8	39.7±6.6	73.6±17	75.3±27.5	160.3±21.9	68.7±2.8	41.1±1.6

Effects of high-purine diet on blood lipid changes and pathological lesion in golden hamsters

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