Abstract: Anti\|disease breeding was effective on preventing infective disease in pigs. Recently， porcine reproductive and respiratory syndrome （PRRS） is severely impacted pig industry. Anti\|PRRSV （porcine reproductive and respiratory syndrome virus， PRRSV） breeding would be an effective solution. In the present paper， research progress on candidate genes for anti\|PRRSV breeding was summarized， including genes of virus receptor， innate immunology， antigen presentation signal pathway and miRNA. Moreover， further research focus on immune tolerance and adaptive immunology of PRRSV were suggested.

Key words: PRRS, anti\, disease breeding, candidate genes, disease tolerance, disease resistance