Abstract: The aflatoxin B1（AFB1） chronic poisoning model of meat ducklings was set up， and the feeding treatments included the normal group， the model group， positive control group （sodium selenite feeding group）， “Compound Chai Qin Particles” groups with high， middle， low doses. Serum， liver and kidney were taken to detect the AFB1 content， blood biochemical and oxidative stress indexes to discuss the pharmacological mechanism of “Compound Chai Qin Particles” in treating duck chronic poisoning of AFB1. Compared with the model group， AFB1 content in liver and kidney decreased significantly in three dose “Compound Chai Qin Particles” groups （P<005）， AKP activity， GOT activity and GPT activity decreased significantly （P<005）， SOD activity increased significantly， but MDA content significantly decreased in serum of the three dose “Compound Chai Qin Particles” groups （P<005）. During 7 or 14 d， the indexes were closer to the normal ones in the middle\|dose of “Compound Chai Qin Particles” group. It was concluded that “Compound Chai Qin Particles” could effectively control ducks chronic poisoning of AFB1， reduce the degree of liver cell membrane damage or cell necrosis， inhibit lipid peroxidation， and increase the antioxidant abilityof liver. And middle\|dose group showed the best effect during the period of 7 d or 14 d after setting up model by AFB1.

Key words:  Compound Chai Qin Particles, aflatoxin B1, high performance liquid chromatography, duck, liver tissue