›› 2017, Vol. 29 ›› Issue (8): 1243-1252.DOI: 10.3969/j.issn.1004-1524.2017.08.04

• Animal Science • Previous Articles     Next Articles

Effects of concentrate level and dietary supplementation of recombinant antimicrobial peptides (AMPs) on growth performance and serum immunoglobulin, cytokines, complement, hormone levels in male Chuanzhong black goats

YANG Yanyi, DENG Junliang*, CHEN Yun, GAO Shuang, LIU Qi, CHEN Chong, YAO Shuhua   

  1. Key Laboratory of Animal Disease & Human Health of Sichuan Province,Key Laboratory of Environmental Hazard and Animal Disease of Sichuan Province,College of Veterinary Medicine,Sichuan Agricultural University,Chengdu 611130,China
  • Received:2017-01-12 Online:2017-08-20 Published:2017-09-06

Abstract: This study is to evaluate the effects of dietary additive of antimicrobial peptides (AMPs) on growth performance, immunoglobulin, cytokines,complement and hormone levels of male Chuanzhong black goats. A total of 24 male goats were allotted to four groups on the basis of initial body weight, each group with 6 goats. Dietary treatments were Ⅰ-normal concentrate group (300 g concentrate), Ⅱ-normal concentrate and antimicrobial peptide group(300 g concentrate+3.0 g antimicrobial peptides), Ⅲ-high concentrate group (600 g concentrates), Ⅳ-high concentrate and antimicrobial peptide group (600 g concentrate+3.0g antimicrobial peptides). After a week of pre-feeding test, the 60 day test was conducted. On 0, 20th, 40th and 60th day, 4 goats were randomly selected from each group, whose jugular vein blood samples were collected to test immunoglobulin, cytokines, complement and hormone levels, and were weighed one by one. The results showed, compared with the control group, the recombinant antimicrobial peptides and high concentrate could significantly increase the levels of immunoglobulin IgA, IgG, IgM, cytokine IL-2, IL-6, IL-10, IL-12, IFN-γ, TNF-α, complement C3, C4, hormone ACTH, IGF-1, T3, T4 in serum, the body weights and average daily gains, which confirmed that the recombinant antimicrobial peptides and high concentrate could enhance the immune function and promote the growth of the goat.

Key words: antimicrobial peptides, immunoglobulin, cytokines, complement, growth hormone

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