Study of anti-inflammatory effects of extracts from Zornia diphylla (L.) Pers in mice

doi:10.3969/j.issn.1004-1524.2018.05.10

›› 2018, Vol. 30 ›› Issue (5): 738-743.DOI: 10.3969/j.issn.1004-1524.2018.05.10

• Animal Science • Previous Articles Next Articles

Study of anti-inflammatory effects of extracts from Zornia diphylla (L.) Pers in mice

CHEN Xiuying, ZHANG Yuchen, XU Xiangkun, FENG Xuejian^*

College of Pharmaceutical Sciences, Research Center of Zhengzhou University Drug Safety Evaluation, Ministry of Education, Key Laboratory of Advanced Drug Preparation Technologies, Zhengzhou University, Zhengzhou 450001, China

Received:2017-08-29 Online:2018-05-20 Published:2018-05-23

Abstract

Abstract: The peritoneal capillary permeability test, xylene induced auricular swelling test and carrageenan induced paw edema test were used to study the anti-inflammatory effect of Zornia diphylla (L.) Pers. Compared with the model control group, Zornia diphylla (L.) Pers inhibited the penetration of capillary vessel, decreased the swelling rate of auricle and paw in mice and relieved the pathological changes of the toes swelling and the exudation of PGE₂ in the inflammatory site after intragastric administration for 5 days. These results showed that Zornia diphylla (L.) Pers had inhibitory effects on acute inflammation in mice, and the mechanism may be related to the reduction of PGE₂ in the inflammatory sites.

Key words: Zornia diphylla (L.) Pers, anti-inflammation, PGE₂, mice

CLC Number:

S859

CHEN Xiuying, ZHANG Yuchen, XU Xiangkun, FENG Xuejian. Study of anti-inflammatory effects of extracts from Zornia diphylla (L.) Pers in mice[J]. , 2018, 30(5): 738-743.

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Study of anti-inflammatory effects of extracts from Zornia diphylla (L.) Pers in mice

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