过氧化物酶体与真菌有性生殖的关系

doi:10.3969/j.issn.1004-1524.20230369

浙江农业学报 ›› 2023, Vol. 35 ›› Issue (10): 2500-2506.DOI: 10.3969/j.issn.1004-1524.20230369

• 综述 • 上一篇

过氧化物酶体与真菌有性生殖的关系

卞美云¹^,²(), 王静², 王教瑜²^,^*(), 陈杰¹

1.浙江农林大学林业与生物技术学院,浙江杭州 311300
2.浙江省农业科学院植物保护与微生物研究所,浙江杭州 310021

收稿日期:2023-08-30 出版日期:2023-10-25 发布日期:2023-10-31
作者简介:卞美云(1996—),女,江苏南通人,硕士,研究方向为真菌分子生物学。E-mail: 1872557318@qq.com
通讯作者: ^*王教瑜,E-mail: wangjiaoyu78@sina.com
基金资助:
浙江省自然科学基金(LZ20C140001);国家自然科学基金(32300169)

The relationship between peroxisome and fungal sexual reproduction

BIAN Meiyun¹^,²(), WANG Jing², WANG Jiaoyu²^,^*(), CHEN Jie¹

1. School of Forestry and Biotechnology, Zhejiang A&F University, Hangzhou 311300, China
2. Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China

Received:2023-08-30 Online:2023-10-25 Published:2023-10-31

摘要/Abstract

摘要：

过氧化物酶体是一种多功能、动态变化的细胞器,对大多数真核生物的发育至关重要。真菌中过氧化物酶体参与多个生长与发育过程,包括有性生殖。真菌有性孢子的形成,通常发生在多细胞的子实体内,需要经过有丝分裂、减数分裂、细胞分化等多个步骤。研究表明,过氧化物酶体在上述过程的调控中发挥作用,是维持子实体形成、有性孢子产生和成熟所必需的。首先,真菌有性生殖依赖菌丝细胞内储藏脂类物质的降解提供能量,而过氧化物酶体内的脂肪酸β-氧化和乙醛酸循环是脂类降解和转化的必需步骤。其次,过氧化物酶体还可能直接参与细胞减数分裂过程。在细胞减数分裂过程中,过氧化物酶体大小、数量和位置都发生规律性的变化。此外,过氧化物酶体还参与有性生殖过程中信号分子的形成,敲除过氧化物酶体形成相关基因会影响真菌子囊壳的形成。

关键词: 过氧化物酶体, 真菌, 有性生殖, 减数分裂, PEX

Abstract:

Peroxisome are multifunctional and dynamic organelles essential for the development in most of the eukaryotes. In fungi, the organelles are involved in divers growth and development processes, including sexual reproduction. The formation of fungal sexual spores, usuallyoccurs in multicellular fruiting bodies, requires multiple steps such as mitosis, meiosis, cell differentiation. Studies have shown that peroxisomes play a role in regulating the above processes and are necessary for sustaining the formation of fruiting bodies, the production and the maturation of sexual spores. Firstly, the morphogenesis of fungal sexual reproduction depends on the degradation of lipid reserves in mycelial cells to supply energy and intermediate molecules, while the fatty acid β-oxidation and the glyoxylate cycle in peroxisomes are necessary steps for lipid degradation and transformation. Secondly, peroxisomes may also be directly involved in the processes of cell meiosis. During cell meiosis, the size, quantity and location of peroxisomes change regularly. In addition, peroxisomes also participate in the formation of signaling molecules during sexual reproduction, and the knockdown of peroxisomal biogenesis-related genes affects the formation of fungal perithecium.

Key words: peroxisome, fungi, sexual reproduction, meiosis, PEX

中图分类号:

卞美云, 王静, 王教瑜, 陈杰. 过氧化物酶体与真菌有性生殖的关系[J]. 浙江农业学报, 2023, 35(10): 2500-2506.

BIAN Meiyun, WANG Jing, WANG Jiaoyu, CHEN Jie. The relationship between peroxisome and fungal sexual reproduction[J]. Acta Agriculturae Zhejiangensis, 2023, 35(10): 2500-2506.

参考文献 60

[1]	FRANSEN M, NORDGREN M, WANG B, et al. Role of peroxisomes in ROS/RNS-metabolism: implications for human disease[J]. Biochimica et Biophysica Acta, 2012, 1822(9): 1363-1373.
[2]	DI CARA F, SAVARY S, KOVACS W J, et al. The peroxisome: an up-and-coming organelle in immunometabolism[J]. Trends in Cell Biology, 2023, 33(1): 70-86.
[3]	PLETT A, CHARTON L, LINKA N. Peroxisomal cofactor transport[J]. Biomolecules, 2020, 10(8): 1174.
[4]	OKUMOTO K, TAMURA S, HONSHO M, et al. Peroxisome: metabolic functions and biogenesis[J]. Advances in Experimental Medicine and Biology, 2020, 1299: 3-17.
[5]	LI Y, THARAPPEL J C, COOPER S, et al. Expression of the hydrogen peroxide-generating enzyme fatty acyl CoA oxidase activates NF-kappaB[J]. DNA and Cell Biology, 2000, 19(2): 113-120.
[6]	BOISSON-DERNIER A, FRIETSCH S, KIM T H, et al. The peroxin loss-of-function mutation abstinence by mutual consent disrupts male-female gametophyte recognition[J]. Current Biology, 2008, 18(1): 63-68.
[7]	BAES M, VAN VELDHOVEN P P. Mouse models for peroxisome biogenesis defects and β-oxidation enzyme deficiencies[J]. Biochimica et Biophysica Acta, 2012, 1822(9): 1489-1500.
[8]	MAST F D, LI J, VIRK M K, et al. A Drosophila model for the Zellweger spectrum of peroxisome biogenesis disorders[J]. Disease Models & Mechanisms, 2011, 4(5): 659-672.
[9]	SZÖOR B, RUBERTO I, BURCHMORE R, et al. A novel phosphatase cascade regulates differentiation in Trypanosoma brucei via a glycosomal signaling pathway[J]. Genes & Development, 2010, 24(12): 1306-1316.
[10]	WATERHAM H R, EBBERINK M S. Genetics and molecular basis of human peroxisome biogenesis disorders[J]. Biochimica et Biophysica Acta(BBA)-Molecular Basis of Disease, 2012, 1822(9): 1430-1441.
[11]	WANG S, YANG H X, FU Y L, et al. The key role of peroxisomes in follicular growth, oocyte maturation, ovulation, and steroid biosynthesis[J]. Oxidative Medicine and Cellular Longevity, 2022, 2022: 7982344.
[12]	TANABE Y, MARUYAMA J I, YAMAOKA S, et al. Peroxisomes are involved in biotin biosynthesis in Aspergillus and Arabidopsis[J]. The Journal of Biological Chemistry, 2011, 286(35): 30455-30461.
[13]	GRÜNDLINGER M, YASMIN S, LECHNER B E, et al. Fungal siderophore biosynthesis is partially localized in peroxisomes[J]. Molecular Microbiology, 2013, 88(5): 862-875.
[14]	MARTÍN J F, ULLÁN R V, GARCÍA-ESTRADA C. Role of peroxisomes in the biosynthesis and secretion of β-lactams and other secondary metabolites[J]. Journal of Industrial Microbiology & Biotechnology, 2012, 39(3): 367-382.
[15]	RAMOS-PAMPLONA M, NAQVI N I. Host invasion during rice-blast disease requires carnitine-dependent transport of peroxisomal acetyl-CoA[J]. Molecular Microbiology, 2006, 61(1): 61-75.
[16]	MCTAGGART A R, JAMES T Y, IDNURM A, et al. Sexual reproduction is the null hypothesis for life cycles of rust fungi[J]. PLoS Pathogens, 2022, 18(5): e1010439.
[17]	SIMONET J M, ZICKLER D. Mutations affecting meiosis in Podospora anserina. I. Cytological studies[J]. Chromosoma, 1972, 37(3): 327-351.
[18]	SIMONET J M, ZICKLER D. Genes involved in caryogamy and meiosis in Podospora anserina[J]. Molecular and General Genetics MGG, 1978, 162(3): 237-242.
[19]	BARTOSZEWSKA M, KIEL J A K W. The role of macroautophagy in development of filamentous fungi[J]. Antioxidants & Redox Signaling, 2011, 14(11): 2271-2287.
[20]	WÖSTEN H A B, WESSELS J G H. The emergence of fruiting bodies in basidiomycetes[M]// Growth, Differentiation and Sexuality. Berlin/Heidelberg: Springer-Verlag, 2006: 393-414.
[21]	MURPHY D J. The dynamic roles of intracellular lipid droplets: from Archaea to mammals[J]. Protoplasma, 2012, 249(3): 541-585.
[22]	LIU J J, LU W, SHI B M, et al. Peroxisomal regulation of redox homeostasis and adipocyte metabolism[J]. Redox Biology, 2019, 24: 101167.
[23]	BINNS D, JANUSZEWSKI T, CHEN Y, et al. An intimate collaboration between peroxisomes and lipid bodies[J]. The Journal of Cell Biology, 2006, 173(5): 719-731.
[24]	FALTER C, REUMANN S. The essential role of fungal peroxisomes in plant infection[J]. Molecular Plant Pathology, 2022, 23(6): 781-794.
[25]	GUENTHER J C, HALLEN-ADAMS H E, BÜCKING H, et al. Triacylglyceride metabolism by Fusarium graminearum during colonization and sexual development on wheat[J]. Molecular Plant-Microbe Interactions, 2009, 22(12): 1492-1503.
[26]	ERENTAL A, DICKMAN M B, YARDEN O. Sclerotial development in Sclerotinia sclerotiorum: awakening molecular analysis of a “Dormant” structure[J]. Fungal Biology Reviews, 2008, 22(1): 6-16.
[27]	LIBERTI D, ROLLINS J A, DOBINSON K F. Peroxysomal carnitine acetyl transferase influences host colonization capacity in Sclerotinia sclerotiorum[J]. Molecular Plant-Microbe Interactions, 2013, 26(7): 768-780.
[28]	LACOURT I, DUPLESSIS S, ABBÀ S, et al. Isolation and characterization of differentially expressed genes in the mycelium and fruit body of Tuber borchii[J]. Applied and Environmental Microbiology, 2002, 68(9): 4574-4582.
[29]	ABBA’S, BALESTRINI R, BENEDETTO A, et al. The role of the glyoxylate cycle in the symbiotic fungus Tuber borchii: expression analysis and subcellular localization[J]. Current Genetics, 2007, 52(3/4): 159-170.
[30]	CECCAROLI P, BUFFALINI M, SALTARELLI R, et al. Genomic profiling of carbohydrate metabolism in the ectomycorrhizal fungus Tuber melanosporum[J]. The New Phytologist, 2011, 189(3): 751-764.
[31]	YOON J J, MUNIR E, MIYASOU H, et al. A possible role of the key enzymes of the glyoxylate and gluconeogenesis pathways for fruit-body formation of the wood-rotting basidiomycete Flammulina velutipes[J]. Mycoscience, 2002, 43(4): 327-332.
[32]	YOON J J, HATTORI T, SHIMADA M. A metabolic role of the glyoxylate and tricarboxylic acid cycles for development of the copper-tolerant brown-rot fungus Fomitopsis palustris[J]. FEMS Microbiology Letters, 2002, 217(1): 9-14.
[33]	MIN K, SON H, LEE J, et al. Peroxisome function is required for virulence and survival of Fusarium graminearum[J]. Molecular Plant-Microbe Interactions, 2012, 25(12): 1617-1627.
[34]	BONNET C, ESPAGNE E, ZICKLER D, et al. The peroxisomal import proteins PEX2, PEX5 and PEX7 are differently involved in Podospora anserina sexual cycle[J]. Molecular Microbiology, 2006, 62(1): 157-169.
[35]	HYNES M J, MURRAY S L, KHEW G S, et al. Genetic analysis of the role of peroxisomes in the utilization of acetate and fatty acids in Aspergillus nidulans[J]. Genetics, 2008, 178(3): 1355-1369.
[36]	MANAGADZE D, WÜRTZ C, SICHTING M, et al. The peroxin PEX14 of Neurospora crassa is essential for the biogenesis of both glyoxysomes and Woronin bodies[J]. Traffic, 2007, 8(6): 687-701.
[37]	KONG X J, ZHANG H, WANG X L, et al. FgPex3, a peroxisome biogenesis factor, is involved in regulating vegetative growth, conidiation, sexual development, and virulence in Fusarium graminearum[J]. Frontiers in Microbiology, 2019, 10: 2088.
[38]	ZHANG L, LIU C J, WANG M Y, et al. Peroxin FgPEX22-like is involved in FgPEX4 tethering and Fusarium graminearum pathogenicity[J]. Frontiers in Microbiology, 2021, 12: 756292.
[39]	WANG L N, ZHANG L, LIU C J, et al. The roles of FgPEX2 and FgPEX12 in virulence and lipid metabolism in Fusarium graminearum[J]. Fungal Genetics and Biology, 2020, 135: 103288.
[40]	NAVARRO-ESPÍNDOLA R, TAKANO-ROJAS H, SUASTE-OLMOS F, et al. Distinct contributions of the peroxisome-mitochondria fission machinery during sexual development of the fungus Podospora anserina[J]. Frontiers in Microbiology, 2020, 11: 640.
[41]	MENDOZA-MENDOZA A, BERNDT P, DJAMEI A, et al. Physical-chemical plant-derived signals induce differentiation in Ustilago maydis[J]. Molecular Microbiology, 2009, 71(4): 895-911.
[42]	VOLLMEISTER E, SCHIPPER K, BAUMANN S, et al. Fungal development of the plant pathogen Ustilago maydis[J]. FEMS Microbiology Reviews, 2012, 36(1): 59-77.
[43]	KLOSE J, KRONSTAD J W. The multifunctional beta-oxidation enzyme is required for full symptom development by the biotrophic maize pathogen Ustilago maydis[J]. Eukaryotic Cell, 2006, 5(12): 2047-2061.
[44]	KRETSCHMER M, KLOSE J, KRONSTAD J W. Defects in mitochondrial and peroxisomal β-oxidation influence virulence in the maize pathogen Ustilago maydis[J]. Eukaryotic Cell, 2012, 11(8): 1055-1066.
[45]	TSITSIGIANNIS D I, KELLER N P. Oxylipins as developmental and host-fungal communication signals[J]. Trends in Microbiology, 2007, 15(3): 109-118.
[46]	MANJITHAYA R, ANJARD C, LOOMIS W F, et al. Unconventional secretion of Pichia pastoris Acb1 is dependent on GRASP protein, peroxisomal functions, and autophagosome formation[J]. The Journal of Cell Biology, 2010, 188(4): 537-546.
[47]	WATERHAM H R, DE VRIES Y, RUSSEL K A, et al. The Pichia pastoris PER6 gene product is a peroxisomal integral membrane protein essential for peroxisome biogenesis and has sequence similarity to the Zellweger syndrome protein PAF-1[J]. Molecular and Cellular Biology, 1996, 16(5): 2527-2536.
[48]	PERAZA-REYES L, ARNAISE S, ZICKLER D, et al. The importomer peroxins are differentially required for peroxisome assembly and meiotic development in Podospora anserina: insights into a new peroxisome import pathway[J]. Molecular Microbiology, 2011, 82(2): 365-377.
[49]	PERAZA-REYES L, ESPAGNE E, ARNAISE S, et al. The role of peroxisomes in the regulation of Podospora anserina sexual development[J]. Research Signpost, 2009: 61-68.
[50]	PERAZA-REYES L, ESPAGNE E, ARNAISE S, et al. Peroxisomes in filamentous fungi[M]// BORKOVICHK A, EBBOLED J.Cellular and Molecular Biology of Filamentous Fungi. Washington, DC, USA: ASM Press, 2014: 191-206.
[51]	BERTEAUX-LECELLIER V, PICARD M, THOMPSON-COFFE C, et al. A nonmammalian homolog of the PAF7 gene(Zellweger syndrome) discovered as a gene involved in caryogamy in the fungus Podospora anserina[J]. Cell, 1995, 81(7): 1043-1051.
[52]	MOTLEY A M, HETTEMA E H. Yeast peroxisomes multiply by growth and division[J]. The Journal of Cell Biology, 2007, 178(3): 399-410.
[53]	SEONG K Y, ZHAO X H, XU J R, et al. Conidial germination in the filamentous fungus Fusarium graminearum[J]. Fungal Genetics and Biology, 2008, 45(4): 389-399.
[54]	GÓMEZ B L, NOSANCHUK J D. Melanin and fungi[J]. Current Opinion in Infectious Diseases, 2003, 16(2): 91-96.
[55]	COPPIN E, SILAR P. Identification of PaPKS1, a polyketide synthase involved in melanin formation and its use as a genetic tool in Podospora anserina[J]. Mycological Research, 2007, 111(8): 901-908.
[56]	WANG Z Y, SOANES D M, KERSHAW M J, et al. Functional analysis of lipid metabolism in Magnaporthe grisea reveals a requirement for peroxisomal fatty acid beta-oxidation during appressorium-mediated plant infection[J]. Molecular Plant-Microbe Interactions, 2007, 20(5): 475-491.
[57]	BOISNARD S, ESPAGNE E, ZICKLER D, et al. Peroxisomal ABC transporters and β-oxidation during the life cycle of the filamentous fungus Podospora anserina[J]. Fungal Genetics and Biology, 2009, 46(1): 55-66.
[58]	HYNES M J, MURRAY S L, ANDRIANOPOULOS A, et al. Role of carnitine acetyltransferases in acetyl coenzyme A metabolism in Aspergillus nidulans[J]. Eukaryotic Cell, 2011, 10(4): 547-555.
[59]	TRAIL F. Fungal cannons: explosive spore discharge in the Ascomycota[J]. FEMS Microbiology Letters, 2007, 276(1): 12-18.
[60]	SON H, MIN K, LEE J, et al. Mitochondrial carnitine-dependent acetyl coenzyme A transport is required for normal sexual and asexual development of the ascomycete Gibberella zeae[J]. Eukaryotic Cell, 2012, 11(9): 1143-1153.

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过氧化物酶体与真菌有性生殖的关系

The relationship between peroxisome and fungal sexual reproduction

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