Research progress of intestinal epithelial tight junction proteins in piglets

doi:10.3969/j.issn.1004-1524.2018.08.23

›› 2018, Vol. 30 ›› Issue (8): 1435-1444.DOI: 10.3969/j.issn.1004-1524.2018.08.23

• Reviews • Previous Articles

Research progress of intestinal epithelial tight junction proteins in piglets

ZONG Qiufang¹, QIN Weiyun¹, HUO Yongjiu^1,2, WU Shenglong^1,2, BAO Wenbin^1,2,*

1. College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China;
2. Jiangsu Innovation Team for the Modern Agriculture (Pig) Excellent Breeding of Industrial Technical System, Yangzhou 225009, China

Received:2017-11-27 Online:2018-08-25 Published:2018-08-28

Abstract

Abstract: Tight junction (TJ) is the main connection form between intestinal epithelial cells. It plays an important role in maintaining intestinal epithelial mechanical barrier and permeability of pig intestinal mucosa. The tight junction proteins are important protein molecules that form the intestinal mucosal barrier and determine the permeability of the intestinal wall, which have a great influence on the composition and function of the tight junctions. Among these proteins, zonula occludens 1 (ZO-1), Occludin (OCLN) and Claudins (CLDN) are the main components of the tight junctions, involving in maintaining the function of cell polarity and tight junction barrier. This review summarized the structure, biological functions and gene expression of tight junction proteins of ZO-1, Occludin and Claudins, then further offered an overview of the recent advances of these proteins for providing theoretical basis for further elucidating the functions of porcine tight junction-related proteins and developing treatment for diseases such as diarrhea and intestinal inflammation.

Key words: pig, intestinal epithelium, intestinal barrier, tight junction protein

CLC Number:

S813.3

ZONG Qiufang, QIN Weiyun, HUO Yongjiu, WU Shenglong, BAO Wenbin. Research progress of intestinal epithelial tight junction proteins in piglets[J]. , 2018, 30(8): 1435-1444.

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Research progress of intestinal epithelial tight junction proteins in piglets

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