Abstract: Based on the results of whole genome association analysis of milk production and reproductive traits of Xinjiang brown cattle, the bioinformatics function of candidate genes were analyzed, and the key genes significantly related to milk production and reproductive traits of Xinjiang Brown cattle were screened out. According to the results of association analysis, 55 candidate genes were found on the basis of physical location of significant single nucleotide polypeptide sites, of which 49 genes could retrieve the corresponding functional annotation information in the database. The results of GO classification showed that these genes were involved in metabolism, transcription and other 30 GO terms. The enrichment analysis of KEGG metabolic pathway showed that the candidate genes were enriched in 7 pathways, of which the largest number of genes were Wnt signaling pathway and cadherin signaling pathway. By reviewing the research progress of the candidate genes and the biological function, physiological and biochemical analysis of the related genes, the next step of gene function study can be carried out on CDH2 and GABRG2 gene in the candidate genes for milk production traits and EPRS gene in the candidate genes for reproductive traits.

Key words: Xinjiang Brown cattle, genome-wide association analysis, function annotation, milk traits, reproduction traits