Genome sequencing and analysis in Asia1 serotype strain of footandmouth disease virus

›› 2014, Vol. 26 ›› Issue (2): 0-290296.

• 动物科学 •

Genome sequencing and analysis in Asia1 serotype strain of footandmouth disease virus

WANG Linxuan;CHEN Simin;ZHANG Yinhong;*;SUN Dongjie

1Nutrition and Food Hygiene Research Institute， College of Public Hygiene， Lanzhou University， Lanzhou 730000， China; 2 Veterinary Research Institute， Chinese Academy of Agricultural Sciences/State Key Laboratory of Veterinary Etiological Biology， Lanzhou 730046， China

Received:1900-01-01 Revised:1900-01-01 Online:2014-03-25 Published:2014-07-09

Abstract

Abstract: In this study， the whole genome of footandmouth disease virus (FMDV) vaccine strain Asia1/JS/2005 in China was amplified and sequenced. The results showed that the complete genome is 8 174 nt， including a 1 092 nt 5’ untranslated region (UTR)， a 6 990 nt open reading frame and a 92 nt 3’UTR. By using the DNAstar software， homology analysis of genome sequences of strain Asia1/JS/2005 and other 24 Asia1 strains were performed. The results indicated that nonstructural proteins and 5’UTR were more conserved. The data revealed novel highly conserved and variable genomic regions， which was likely associated with biological function. Phylogenetic tree revealed that Asia1/JS/2005 is closely linked with Asia1/1/YZ/2006， Asia1/WHN/2006， Asia1/HN/2006 and Asia1/YS/2005， which suggested that they were genetically associated and Asia1/YS/05 was the most closely related strain with Asia1/JS/2005．

Key words: footandmouth disease virus, Asia1/JS/2005, genome

WANG Linxuan;CHEN Simin;ZHANG Yinhong;*;SUN Dongjie. Genome sequencing and analysis in Asia1 serotype strain of footandmouth disease virus[J]. , 2014, 26(2): 0-290296.

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Genome sequencing and analysis in Asia1 serotype strain of footandmouth disease virus

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