Adjuvant effect of glycyrrhetinic acid liposome on the immune responses to ovalbumin in mice#br#

Adjuvant effect of glycyrrhetinic acid liposome on the immune responses to ovalbumin in mice#br#

（1 National Research Center of Veterinary Biologicals Engineering and Technology， Jiangsu Academy of Agricultural Sciences， Nanjing 210014， China; 2 College of Veterinary Medicine, Nanjing Agricultural University， Nanjing 210014， China）

Online:2015-08-25 Published:2015-08-21

Abstract

Abstract: In order to study the action mechanism of glycyrrhetinic acid liposome （GAL）， 100 mice were vaccinated by ovalbumin along with glycyrrhetinic acid liposome （GAL）， glycyrrhetinic acid （GA）， liposome （BL） or oil （OIL） in four groups. Blood samples were collected to measure antibody titers， IL\|2 and IFN\|γ by ELISA assay; cell mediated immune response was detected by MTT assay. The results showed that GAL could improve the secretion of IgG， IL\|2 and IFN\|γ， and significantly promote lymphocyte proliferation in comparison with glycyrrhetinic acid， liposome and oil. The present study demonstrated that the activity of glycyrrhetinic acid encapsulated with liposome was enhanced.

Key words: glycyrrhetinic acid liposome, mice, immune enhancement

LU Yu1，ZHAO Xiao\|juan1，HUANG Ye\|e2，YU Yun2，WANG De\|yun2，*. Adjuvant effect of glycyrrhetinic acid liposome on the immune responses to ovalbumin in mice#br#[J]. .

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Adjuvant effect of glycyrrhetinic acid liposome on the immune responses to ovalbumin in mice#br#

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