Abstract: In order to reveal breed differences and tissue differences of CPT\|1A mRNA levels in Guizhou native goats and Nanjiang yellow goats， Qiandongnan small\|Xiang goats， Guizhou white goats， Guizhou black goats， Qianbei Ma goats and Nanjiang yellow goats were used as subjects， and expression levels of CPT\|1A mRNA in livers， kidneys， hearts， lungs， longissimus muscle， amnion muscle and subcutaneous adipose were detected by real\|time fluorescence quantitative RT\|PCR. The results showed that the highest expression level （0.0019 and 0.0019） of CPT\|1A mRNA in Qianbei Ma goat and Nanjiang yellow goat were observed in kidney. Similarly， the highest expression levels were observed in liver （0.0074） of Guizhou black goat， and longissimus muscle （0.0011） of Guizhou white goat as well. There were no significant difference among tissues in Qiandongnan small\|Xiang goat. The highest expression levels of CPT\|1A mRNA in heart（0.0018） and kidney（0.0019） were observed in Nanjiang yellow goat， which in liver （0.0074） and lung （0.0027） were observed in Guizhou black goat， and in subcutaneous adipose （0.0007） were observed in Qiandongnan small\|Xiang goat. There were no difference in longissimus muscle and amnion muscle among different breeds. The results suggested that tissue distribution models of CPT\|1A mRNA in Guizhou white goat breed， Guizhou black goat breed， Qianbei Ma goat breed and Nanjiang yellow goat breed were different， and expression levels of CPT\|1A gene in liver， kidney， heart， lung and subcutaneous adipose of different breeds were also different. This results provided the theoretical basis for study on the relationship between fat deposition or meat quality traits of Guizhou native goat breeds and CPT\|1A gene.

Key words: Guizhou native goat, Nanjiang yellow goat, CPT\, 1A, gene expression