Abstract: The aim of this study was to observe the pathological lesions of multiple organs from giant pandas died of multiple organ dysfunction caused by primary liver cancer, and to explore the pathological features of giant panda hepatocellular carcinoma. The giant panda “Panpan” was 31 years old, male, died on December 28, 2016. After systemic anatomy, the liver, pancreas, stomach, duodenum, colon, rectum, heart, lung, kidney, bladder, spleen, thyroid, submandibular gland, mesenteric lymph node, submandibular lymph node, testis, perianal skin tissue, forelimb muscle, hind limb muscle and whole body tumor tissue were took for hematoxylineosin (HE) staining. Ascites, nodular hyperplasia of the liver surface, a large number of bleeding points in the distal rectum, part of the splenomegaly, scattered small nodules in the perianal skin, scattered nodules in the skin inside the right scrotum were found, and the tumors in its right armpit, left lobe of the liver, diaphragm, peritoneum and mesentery in autopsy could be seen clearly. HE staining results showed that multifocal abscesses were observed in the liver tissue, a part of hepatocytes were necrotic and polygonal, hepatocytes arranged in adenoid and pebble-like structure, cells were dysplasia, the ratio of nuclear to cytoplasm and cell density increased, atypical cell clumps were observed in renal tissue. Heart, lung, pancreas, duodenum, rectum, spleen, bladder, thyroid, mesenteric lymph nodes, submandibular lymph nodes, testis, perianal skin, forelimb muscle and hind limb muscle all had pathological damage. The results suggested that the giant panda died due to multiple organ dysfunction or even failure, which was suspected to be a large area of primary liver cancer caused by the rapid transfer of the adjacent.

Key words: giant panda, primary liver cancer, hepatocellular carcinoma, pathology