Virus-host interaction: an overview on recent advances in porcine circovirus type 3

doi:10.3969/j.issn.1004-1524.20230183

Acta Agriculturae Zhejiangensis ›› 2023, Vol. 35 ›› Issue (7): 1755-1762.DOI: 10.3969/j.issn.1004-1524.20230183

Virus-host interaction: an overview on recent advances in porcine circovirus type 3

SUN Renjie¹^,²(), SHAN Ying²^,³, AN Huiting¹, WANG Yating¹, XIE Ronghui¹, ZHANG Chuanliang¹, ZHAO Ling-yan¹, FANG Weihuan²^,³, LI Xiaoliang²^,³^,^*()

1. Zhejiang Provincial Center for Animal Disease Prevention & Control, Hangzhou 311199, China
2. Zhejiang Provincial Key Lab of Preventive Veterinary Medicine, Hangzhou 310058, China
3. College of Animal Sciences, Zhejiang University, Hangzhou 310058, China

Received:2023-02-17 Online:2023-07-25 Published:2023-08-17
Contact: LI Xiaoliang

Abstract

Abstract:

Porcine circovirus type 3 (PCV3) is an important emerging pathogen of swine disease, which has been reported in swine industry of several countries and regions since its discovery in 2015. Current understanding of PCV3 pathogenesis is limited. The majority of studies are focus on the retrospective investigation, genetic characterization, phylogenetic analysis and establishment of detection methods. PCVs-host relationship is close and complex, which involves various cellular and viral processes. The interaction between them determines cell fate and transmission and survival of PCVs. Recently, some researchers have conducted studies on the PCV3-host interaction at the virus component or whole virus level by utilizing transient expression system, clinical isolation and propagation and reverse genetics system. This review summarizes the recent progress on host response to viral infection, virus-host proteins interaction and viral life cycle, and could be helpful in understanding PCV3 pathogenesis.

Key words: porcine circovirus type 3, host response, viral life cycle

CLC Number:

S852.65

SUN Renjie, SHAN Ying, AN Huiting, WANG Yating, XIE Ronghui, ZHANG Chuanliang, ZHAO Ling-yan, FANG Weihuan, LI Xiaoliang. Virus-host interaction: an overview on recent advances in porcine circovirus type 3[J]. Acta Agriculturae Zhejiangensis, 2023, 35(7): 1755-1762.

Figures/Tables 2

References 40

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宿主互作蛋白 Host interacting proteins	功能 Function	参考文献 Reference
G3BP1	应激颗粒的形成和Ras通路的信号转导 Assembles stress granules, signal transduction of Ras pathway	[26-27]
KPNA1	细胞质-核之间的蛋白质运输Nuclear protein import	[26, 28]
STAT2	调控IFN相关信号通路基因的转录表达 Regulate the transcriptional expression of IFN-related signaling pathway gene	[26, 28]
NPM1	参与中心体复制和核糖体生物发生Centrosome duplication, ribosome biogenesis	[29, 35]
NCL	rRNA前体的成熟和核糖体前体的组装pre-rRNA processing, Ribosome assembly	[35]
DDX21	调控核糖体RNA的加工Promotes rRNA processing and modification	[35]
hnRNPA2/B1	DNA修复、mRNA前体的剪接、RNA核输出 DNA repairing, pre-mRNA processing, RNA nuclear export	[35]
YTHDF1	mRNA m⁶A修饰和维持mRNA稳定 Specifically recognizes and binds N6-methyladenosine (m⁶A)-containing mRNAs, maintain mRNA stability	[35]
YBX1	维持mRNA稳定和mRNA剪接RNA stabilization and mRNA splicing	[35]

宿主互作蛋白 Host interacting proteins	功能 Function	参考文献 Reference
G3BP1	应激颗粒的形成和Ras通路的信号转导 Assembles stress granules, signal transduction of Ras pathway	[26-27]
KPNA1	细胞质-核之间的蛋白质运输Nuclear protein import	[26, 28]
STAT2	调控IFN相关信号通路基因的转录表达 Regulate the transcriptional expression of IFN-related signaling pathway gene	[26, 28]
NPM1	参与中心体复制和核糖体生物发生Centrosome duplication, ribosome biogenesis	[29, 35]
NCL	rRNA前体的成熟和核糖体前体的组装pre-rRNA processing, Ribosome assembly	[35]
DDX21	调控核糖体RNA的加工Promotes rRNA processing and modification	[35]
hnRNPA2/B1	DNA修复、mRNA前体的剪接、RNA核输出 DNA repairing, pre-mRNA processing, RNA nuclear export	[35]
YTHDF1	mRNA m⁶A修饰和维持mRNA稳定 Specifically recognizes and binds N6-methyladenosine (m⁶A)-containing mRNAs, maintain mRNA stability	[35]
YBX1	维持mRNA稳定和mRNA剪接RNA stabilization and mRNA splicing	[35]

Virus-host interaction: an overview on recent advances in porcine circovirus type 3

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