Advances of function, expression of animal selenoproteins and their regulation mechanism on meat quality

doi:10.3969/j.issn.1004-1524.2021.09.22

Acta Agriculturae Zhejiangensis ›› 2021, Vol. 33 ›› Issue (9): 1779-1788.DOI: 10.3969/j.issn.1004-1524.2021.09.22

• Review • Previous Articles

Advances of function, expression of animal selenoproteins and their regulation mechanism on meat quality

GUO Jia¹^,²(), MEN Xiaoming², DENG Bo², XU Ziwei²^,^*()

1. College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua 321001, China
2. Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China

Received:2021-02-07 Online:2021-09-25 Published:2021-10-09
Contact: XU Ziwei

Abstract

Abstract:

Selenoproteins are the main forms of selenium (Se) metabolism, which play physiological function in animals. The expression regulation of selenoproteins is closely related to animal growth and meat quality. In this paper, the absorption, metabolism and main forms of Se in animals were reviewed. The research progress was systematically summarized on molecular structure, classification, tissue distribution, biological functions, synthesis process and regarding influence factors, and the candidate functional genes of selenoproteins in animals. Moreover, the function of selenoproteins in living muscle and their role on meat quality of livestock and poultry were analyzed. The review would provide scientific basis for the development of new feed additives and the control of meat quality.

Key words: selenoprotein, function, expression regulation, meat quality

CLC Number:

S852.2

GUO Jia, MEN Xiaoming, DENG Bo, XU Ziwei. Advances of function, expression of animal selenoproteins and their regulation mechanism on meat quality[J]. Acta Agriculturae Zhejiangensis, 2021, 33(9): 1779-1788.

Figures/Tables 2

References 63

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功能分类 Functional classification	名称 Name	简写 Abbreviation	生理功能 Physiological function	分布 Distribution
氧化还原功能 Redox function	谷胱甘肽过氧化物酶1 Glutathione peroxidase 1	GPX1	减少细胞内H₂O₂,参与胰岛素信号转导 Reduce intracellular H₂O₂, participated in insulin signal transduction	细胞质、线粒体 Cytoplasm, mitochondria
	谷胱甘肽过氧化物酶2 Glutathione peroxidase 2	GPX2	减少胃肠道过氧化物,抑制炎症反应 Reduce gastrointestinal peroxides, inhibit inflammation	消化道上皮细胞 Digestive tract epithelial cells
	谷胱甘肽过氧化物酶3 Glutathione peroxidase 3	GPX3	减少血浆过氧化物,抑制血栓形成 Reduce plasma peroxides, inhibit thrombosis	血浆 Plasma
	谷胱甘肽过氧化物酶4 Glutathione peroxidase 4	GPX4	减少脂质过氧化物,调节铁死亡和胚胎发育 Reduce lipid peroxides, regulate iron death and embryonic development	体细胞、生殖细胞 Somatic cells, germ cells
	谷胱甘肽过氧化物酶6 Glutathione peroxidase 6	GPX6	修复嗅觉系统,调节精子头部获能 Repair the olfactory system, regulate sperm head capacitation	嗅觉和生殖细胞 Olfaction and germ cells
	硫氧还蛋白还原酶1 Thioredoxin reductase 1	TXNRD1	还原硫氧还蛋白二硫键,影响胚胎发育 Reduced thioredoxin disulfide bond, influence embryonic development	细胞质、细胞核 Cytoplasm, nucleus
	硫氧还蛋白还原酶2 Thioredoxin reductase 2	TXNRD2	还原硫氧还蛋白和谷氧还蛋白,影响胚胎发育 Reduced thioredoxin and glutaredoxin, influence embryonic development	线粒体 Mitochondria
	硫氧还蛋白还原酶3 Thioredoxin reductase 3	TXNRD3	二硫键形成,催化GPx和TXN系统特异反应,促进精子成熟 Form disulfide bond, catalyze the specific reaction of GPx and TXN system, promote sperm mature	睾丸 Testis
	硒蛋白K Selenoprotein K	SELENOK	调节内质网Ca²⁺流量 Regulate the Ca²⁺ flow of endoplasmic reticulum	内质网 Endoplasmic reticulum
	硒蛋白W Selenoprotein W	SELENOW	调节细胞周期,抗炎作用,免疫作用 Regulate cell cycle, anti-inflammatory effect, immune effect	细胞质、细胞核 Cytoplasm, nucleus
	硒蛋白R Selenoprotein R	MSRB1	还原甲硫氨酸亚砜化合物 Reduced methionine sulfoxide compound	细胞质、细胞核 Cytoplasm, nucleus
	硒蛋白H Selenoprotein H	SELENOH	核仁氧化还原酶 Nucleolar oxidoreductase	细胞核 Nucleus
	硒蛋白T Selenoprotein T	SELENOT	参与神经细胞Ca²⁺调节 Participated in nerve cell Ca²⁺ regulation	内质网 Endoplasmic reticulum
	硒蛋白O Selenoprotein O	SELENOO	与线粒体氧化还原反应有关 Related to mitochondrial redox reaction	线粒体 Mitochondria
甲状腺激素代谢调节功能 Regulatory function of thyroid hormone metabolism	1型脱碘酶 Type 1 deiodoinases	DIO1	参与甲状腺激素代谢 Participated in thyroid hormone metabolism	细胞膜 Cell membrane
	2型脱碘酶 Type 2 deiodoinases	DIO2	参与甲状腺激素代谢 Participated in thyroid hormone metabolism	内质网、细胞核 Endoplasmic reticulum, nucleus
	3型脱碘酶 Type 3 deiodoinases	DIO3	参与甲状腺激素分解代谢 Participated in thyroid hormone catabolism	细胞膜、细胞核 Cell membrane, nucleus
硒蛋白转运合成功能 Transport and synthesis function of selenoprotein	硒磷酸合成酶2 Selenophosphate synthetase 2	SEPHS2	合成硒磷酸 Synthetic selenophosphate	细胞质 Cytoplasm
	硒蛋白P Selenoprotein P	SELENOP	转运Se元素,参与胰岛素信号转导 Se transport, participated in insulin signal transduction	细胞外 Extracellular
蛋白质折叠功能 Protein folding function	硒蛋白F Selenoprotein F	SELENOF	影响癌症与白内障发生 Influence cancer and cataract occurrence	内质网 Endoplasmic reticulum
	硒蛋白S Selenoprotein S	SELENOS	抗炎作用、调节细胞因子产生 Anti-inflammatory effect, regulate cytokine production	内质网 Endoplasmic reticulum
	硒蛋白N Selenoprotein N	SELENON	与肌肉稳定、功能有关 Related to muscle stability and function	内质网 Endoplasmic reticulum
其他功能 Other functions	硒蛋白M Selenoprotein M	SELENOM	参与能量代谢调节 Participated in energy metabolism regulation	内质网、高尔基体 Endoplasmic reticulum, Golgi
	硒蛋白Ⅰ Selenoprotein Ⅰ	SELENOI	参与磷脂生物合成 Participated in phospholipid biosynthesis	生物膜 Cell membrane
	硒蛋白V Selenoprotein V	SELENOV	抵抗氧化应激、抑制细胞凋亡 Resist oxidative stress and inhibit cytotoxicity	睾丸 Testis

功能分类 Functional classification	名称 Name	简写 Abbreviation	生理功能 Physiological function	分布 Distribution
氧化还原功能 Redox function	谷胱甘肽过氧化物酶1 Glutathione peroxidase 1	GPX1	减少细胞内H₂O₂,参与胰岛素信号转导 Reduce intracellular H₂O₂, participated in insulin signal transduction	细胞质、线粒体 Cytoplasm, mitochondria
	谷胱甘肽过氧化物酶2 Glutathione peroxidase 2	GPX2	减少胃肠道过氧化物,抑制炎症反应 Reduce gastrointestinal peroxides, inhibit inflammation	消化道上皮细胞 Digestive tract epithelial cells
	谷胱甘肽过氧化物酶3 Glutathione peroxidase 3	GPX3	减少血浆过氧化物,抑制血栓形成 Reduce plasma peroxides, inhibit thrombosis	血浆 Plasma
	谷胱甘肽过氧化物酶4 Glutathione peroxidase 4	GPX4	减少脂质过氧化物,调节铁死亡和胚胎发育 Reduce lipid peroxides, regulate iron death and embryonic development	体细胞、生殖细胞 Somatic cells, germ cells
	谷胱甘肽过氧化物酶6 Glutathione peroxidase 6	GPX6	修复嗅觉系统,调节精子头部获能 Repair the olfactory system, regulate sperm head capacitation	嗅觉和生殖细胞 Olfaction and germ cells
	硫氧还蛋白还原酶1 Thioredoxin reductase 1	TXNRD1	还原硫氧还蛋白二硫键,影响胚胎发育 Reduced thioredoxin disulfide bond, influence embryonic development	细胞质、细胞核 Cytoplasm, nucleus
	硫氧还蛋白还原酶2 Thioredoxin reductase 2	TXNRD2	还原硫氧还蛋白和谷氧还蛋白,影响胚胎发育 Reduced thioredoxin and glutaredoxin, influence embryonic development	线粒体 Mitochondria
	硫氧还蛋白还原酶3 Thioredoxin reductase 3	TXNRD3	二硫键形成,催化GPx和TXN系统特异反应,促进精子成熟 Form disulfide bond, catalyze the specific reaction of GPx and TXN system, promote sperm mature	睾丸 Testis
	硒蛋白K Selenoprotein K	SELENOK	调节内质网Ca²⁺流量 Regulate the Ca²⁺ flow of endoplasmic reticulum	内质网 Endoplasmic reticulum
	硒蛋白W Selenoprotein W	SELENOW	调节细胞周期,抗炎作用,免疫作用 Regulate cell cycle, anti-inflammatory effect, immune effect	细胞质、细胞核 Cytoplasm, nucleus
	硒蛋白R Selenoprotein R	MSRB1	还原甲硫氨酸亚砜化合物 Reduced methionine sulfoxide compound	细胞质、细胞核 Cytoplasm, nucleus
	硒蛋白H Selenoprotein H	SELENOH	核仁氧化还原酶 Nucleolar oxidoreductase	细胞核 Nucleus
	硒蛋白T Selenoprotein T	SELENOT	参与神经细胞Ca²⁺调节 Participated in nerve cell Ca²⁺ regulation	内质网 Endoplasmic reticulum
	硒蛋白O Selenoprotein O	SELENOO	与线粒体氧化还原反应有关 Related to mitochondrial redox reaction	线粒体 Mitochondria
甲状腺激素代谢调节功能 Regulatory function of thyroid hormone metabolism	1型脱碘酶 Type 1 deiodoinases	DIO1	参与甲状腺激素代谢 Participated in thyroid hormone metabolism	细胞膜 Cell membrane
	2型脱碘酶 Type 2 deiodoinases	DIO2	参与甲状腺激素代谢 Participated in thyroid hormone metabolism	内质网、细胞核 Endoplasmic reticulum, nucleus
	3型脱碘酶 Type 3 deiodoinases	DIO3	参与甲状腺激素分解代谢 Participated in thyroid hormone catabolism	细胞膜、细胞核 Cell membrane, nucleus
硒蛋白转运合成功能 Transport and synthesis function of selenoprotein	硒磷酸合成酶2 Selenophosphate synthetase 2	SEPHS2	合成硒磷酸 Synthetic selenophosphate	细胞质 Cytoplasm
	硒蛋白P Selenoprotein P	SELENOP	转运Se元素,参与胰岛素信号转导 Se transport, participated in insulin signal transduction	细胞外 Extracellular
蛋白质折叠功能 Protein folding function	硒蛋白F Selenoprotein F	SELENOF	影响癌症与白内障发生 Influence cancer and cataract occurrence	内质网 Endoplasmic reticulum
	硒蛋白S Selenoprotein S	SELENOS	抗炎作用、调节细胞因子产生 Anti-inflammatory effect, regulate cytokine production	内质网 Endoplasmic reticulum
	硒蛋白N Selenoprotein N	SELENON	与肌肉稳定、功能有关 Related to muscle stability and function	内质网 Endoplasmic reticulum
其他功能 Other functions	硒蛋白M Selenoprotein M	SELENOM	参与能量代谢调节 Participated in energy metabolism regulation	内质网、高尔基体 Endoplasmic reticulum, Golgi
	硒蛋白Ⅰ Selenoprotein Ⅰ	SELENOI	参与磷脂生物合成 Participated in phospholipid biosynthesis	生物膜 Cell membrane
	硒蛋白V Selenoprotein V	SELENOV	抵抗氧化应激、抑制细胞凋亡 Resist oxidative stress and inhibit cytotoxicity	睾丸 Testis

Advances of function, expression of animal selenoproteins and their regulation mechanism on meat quality

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