Abstract: Based on matrix solid\|phase dispersion （MSPD） pretreatment and gas chromatography\|mass spectrometry （GC\|MS）， a method for simultaneous determination of four types of pesticide residues （organophosphorus， organochlorine， pyrethroid and carbamate） in cucumber was developed by optimizing the parameters of pretreatment and GC\|MS. Results indicated that the linear relation between peak area and concentration of the 50 pesticides in the range of 50 μg·L-1 to 1 000 μg·L-1 were good， and the correlation coefficients of most pesticides were higher than 099 （from 0.973 0 to 0.999 7）. The detection limits of 50 pesticides was 1-2 μg·kg-1. The recoveries of 50 pesticides ranged from 70% to 100% at the 50 μg·kg-1 spiking levels， while at the level of 10 μg·kg-1， there were only 45 pesticides. Besides， the relative standard deviations （RSDs） ranged from 0.23% to 15.42%. Thus， the research provided a sensitive， rapid， simple， and accurate analysis method for the simultaneous determination of four types of pesticide residues in cucumber. It was appropriate for the simultaneous identification and quantification of multi\|residues in cucumber.

Key words: matrix solid\, phase dispersion\, GC\, MS, pesticide, cucumber